Diffusion gradient bioreactor and extracorporeal liver device us

Chemistry: molecular biology and microbiology – Apparatus – Bioreactor

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435 12, 435289, 435370, 435375, 21050021, B01D 6300, C12N 500

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active

058277293

ABSTRACT:
A tissue engineering bioreactor is disclosed for growing three-dimensional tissue. Cells are seeded onto a mesh and provided with two media flows, each contacting a different side of the cells. The media flows contain different concentrations of nutrients, allowing nutrients to be delivered to the cells by diffusion gradient. The bioreactor can be used to grow liver tissue, and designed as an extracorporeal liver assist device in which blood or plasma is exposed to the three-dimensional liver tissue. The blood or plasma from a patient directed to flow against the liver tissue. The liver tissue is further exposed on its opposite side to media providing nutrients and gases. The device provides porous boundaries between the blood or plasma, tissue, and media, allowing nutrient and protein delivery by diffusion gradient to dialyze a patient's blood.

REFERENCES:
patent: 3734851 (1973-05-01), Matsumura
patent: 3997396 (1976-12-01), Delente
patent: 4107937 (1978-08-01), Chmiel
patent: 4117881 (1978-10-01), Williams et al.
patent: 4200689 (1980-04-01), Knazek et al.
patent: 4853324 (1989-08-01), Viles et al.
patent: 5043260 (1991-08-01), Jauregui
patent: 5081035 (1992-01-01), Halberstadt et al.
patent: 5266480 (1993-11-01), Naughton et al.
patent: 5270192 (1993-12-01), Li et al.
patent: 5290684 (1994-03-01), Kelly
patent: 5510254 (1996-04-01), Naughton et al.
patent: 5605835 (1997-02-01), Hu et al.
Gunn, 1938, "Hereditary Alcoholic Jaundice," J. of Heredity 29:137-139.
Rapoport, 1958, "The Structural and Functional Unit in the Human Liver (Liver Acinus)," Anat. Rec. 130:673-689.
Cornelius et al., 1972, "Animal Model of Human Disease," Am. J. Pathology 69:369-372.
Jungermann et al., 1982, "The Glucose/Glucose-6-Phosphate Cycle in the Periportal and Perivenous Zone of Rat Liver," Eur. J. Biochem. 123:429-436.
Thurman and Kaufmann, 1985, "Sublobular Compartmentation of Pharmacologic Events (SCOPE): Metabolic Fluxes in Periportal and Pericentral Regions of the Liver Lobule," Hepatology 5: 144-151.
Haussinger and Gerok, 1986, "Metabolism of Amino Acids and Ammonia," In: Regulation Of Hepatic Metabolism. Intra-And Intercellular Compartmentation, Thurman RG, Kaufman FC, Jungermann K, eds., New York, Plenum, 253-291.
Naughton et al., 1987, "Hematopoiesis on Nylon Mesh Templates. I. Long Term Culture of Rat Bone Marrow Cells," J. Med. 18:219-250.
Traber et al., 1988, "Physiologic Significance and Regulation of Hepatocellular Heterogeneity," Gastroenterology 95:1130-1143.
Naughton et al., 1989, "A Physiological Skin Model for In Vitro Toxicity Studies," 183-189, Alternative Methods in Toxicology. In Vitro Toxicology: New Directions vol. 7, (A.M. Goldberg, ed.) Mary Ann Liebert Publishers, New York.
Naughton et al., 1989, "Hematopoiesis on Nylon Mesh Templates," Ann. NY Acad. Sci. 554:125-140.
Naughton et al., 1991, "Long Term Liver Cell Cultures as Potential Substrates for Toxicity Assessment," 193-202, In Vitro Toxicology: Mechanisms and New Technology (A.M. Goldberg, ed.) Mary Ann Liebert Publishers, New York).
Takahashi et al., 1991, Digestive Diseases and Sciences 36(9):1327-1340.
Landeen et al., 1992, "Characterization of Human Dermal Replacement," Wounds 4:167-175.
Chowdhury et al., 1993, "Gunn Rat: An Animal Model for Deficiency of Bilirubin Conjugation," Hepatic Transport and Bile Secretion, Travolini and Berk, eds., Raven Press, NY, pp. 713-719.
Goresky et al., 1993, "Kinetic Models of Hepatic Transport at the Organ Level", 11-53, In: Hepatic Transport and Bile Secretion: Physiology and Pathophysiology, Tavoloni N and Berk PD, eds., Raven Press, NY.
Langer et al., 1993, "Tissue Engineering," Science 260:920-926.
Slivka et al., 1993, "Characterization, Barrier Function, and Drug Metabolism of an In Vitro Skin Model," J. Invest. Dermatol. 100:40-46.
Halberstadt et al., 1994, "The In Vitro Growth of a Three-Dimensional Human Dermal Replacement Using a Single-Pass Perfusion System," Biotechnology and Bioengineering 43:740-746.

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