Diffusion gradient bioreactor and extracorporeal liver device

Details Diffusion gradient bioreactor and extracorporeal liver device Diffusion gradient bioreactor and extracorporeal liver device

1998-08-19

1999-12-28

Lankford, Jr., Leon B.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Solid support and method of culturing cells on said solid...

435 11, 435 12, 435 2, 435325, 435370, 435373, 435395, 435401, 4352891, 4352971, 4352972, 4352981, 4352991, A01N 102, C12N 500, C12M 100, C12M 300, C12M 306

Patent

active

060080493

ABSTRACT:
A tissue engineering bioreactor is disclosed for growing three-dimensional tissue. Cells are seeded onto a mesh and provided with two media flows, each contacting a different side of the cells. The media flows contain different concentrations of nutrients, allowing nutrients to be delivered to the cells by diffusion gradient. The bioreactor can be used to grow liver tissue, and designed as an extracorporeal liver assist device in which blood or plasma is exposed to the three-dimensional liver tissue. The blood or plasma from a patient directed to flow against the liver tissue. The liver tissue is further exposed on its opposite side to media providing nutrients and gases. The device provides porous boundaries between the blood or plasma, tissue, and media, allowing nutrient and protein delivery by diffusion gradient to dialyze a patient's blood.

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