Diffusion cell for ex-vivo pressure-controlled transcorneal drug

Chemistry: molecular biology and microbiology – Apparatus – Differentiated tissue perfusion or preservation apparatus

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4352861, 4352866, 4352871, 4352971, C12M 300

Patent

active

057892407

ABSTRACT:
A diffusion cell for ex-vivo transcorneal drug penetration studies. The diffusion cell design enables control of the pressure and the flow in the acceptor chamber, and can be used for in-vitro studies of the effect of intraocular pressure on transcorneal drug penetration. Validation tests were carried out and reproducible results of the transcorneal drug penetration experiments were obtained with a practical experiment protocol.

REFERENCES:
patent: 4667504 (1987-05-01), Hobson
patent: 4686190 (1987-08-01), Cramer et al.
patent: 5030575 (1991-07-01), Stofac
patent: 5141873 (1992-08-01), Steudl et al.
patent: 5591636 (1997-01-01), Grass

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