Diffusion bioassay for the quantitative determination of mutagen

Details Diffusion bioassay for the quantitative determination of mutagen Diffusion bioassay for the quantitative determination of mutagen

1979-09-17

1982-10-05

Hruskoci, Peter A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 29, 435 32, 435240, C12Q 168

Patent

active

043528805

ABSTRACT:
A quantitative bioassay employing the well known diffusion bioassay is described herein. The bioassay allows the calculation of the minimum concentration of a test agent which produces mutation in a tester strain of cells employed in the diffusion bioassay. A novel method for determining the stability of the agent tested in the test environment is also described.

REFERENCES:
patent: 3493772 (1970-02-01), Daughters et al.
patent: 3819490 (1974-06-01), Klingstrom et al.
patent: 4066510 (1978-01-01), Thilly
Ames, "Identifying Envir. Chemicals Causing Mutations & Cancer," Science, vol. 204, May 11, 1979, pp. 587-593.
Ames et al., "Does Carcinogenic Potency Correlate with Mutagenic Potency in the Ames Assay," Nature, vol. 274, Jul. 6, 1978, pp. 19 and 20.
Ames et al., "Methods for Detecting Carcinogens & Mutagens with the Salmonella/Mammalian-Microsome Mutagenicity Test," Mutation Research, 1975, pp. 347-364.
Devoret, "Bacterial Tests for Potential Carcinogens," Scientific American, Aug. 1979, pp. 40-49.
Hewitt, Microbiological Bioassay, Academic Press, New York, 1977.

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