Diffraction grating-based encoded micro-particles for...

Details Diffraction grating-based encoded micro-particles for... Diffraction grating-based encoded micro-particles for...

2008-03-25

2008-03-25

Lavarias, Arnel (Department: 2872)

Optical: systems and elements

Diffraction

From grating

C435S288700, C436S518000

Reexamination Certificate

active

07349158

ABSTRACT:
Microparticles8includes an optical substrate10having at least one diffraction grating12disposed therein. The grating12having a plurality of colocated pitches Λ which represent a unique identification digital code that is detected when illuminated by incident light24. The incident light24may be directed transversely from the side of the substrate10with a narrow band (single wavelength) or multiple wavelength source, in which case the code is represented by a spatial distribution of light or a wavelength spectrum, respectively. The code may be digital binary or may be other numerical bases. The micro-particles8can provide a large number of unique codes, e.g., greater than 67 million codes, and can withstand harsh environments. The micro-particles8are functionalized by coating them with a material/substance of interest, which are then used to perform multiplexed experiments involving chemical processes, e.g., DNA testing and combinatorial chemistry.

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