Differentiation- or regeneration-inducing agent for alveoli

Details Differentiation- or regeneration-inducing agent for alveoli Differentiation- or regeneration-inducing agent for alveoli

2005-03-07

2010-11-23

Allen, Marianne P (Department: 1647)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S350000, C530S399000

Reexamination Certificate

active

07838494

ABSTRACT:
The present invention provides an agent comprising HGF for inducing differentiation of bone marrow cells into alveolar cells. The present invention also provides an HGF-containing agent for alveolar formation in pulmonary emphysema and the like in which alveoli are destroyed.

REFERENCES:
patent: 5888965 (1999-03-01), Kmiecik et al.
patent: 6172207 (1994-06-01), None
patent: 8268906 (1996-10-01), None
Y. Sakamaki et al., “Hepatocyte Growth Factor Stimulates Proliferation of Respiratory Epithelial Cells during Postpneumonectomy Compensatory Lung Growth in Mice”, American Journal of Respiratory Cell and Molecular Biology, vol. 26, No. 5, pp. 525-533, May 2002.
R. J. Mason et al., “Hepatocyte Growth Factor: The Key to Alveolar Septation?”, American Journal of Respiratory Cell and Molecular Biology, vol. 26, No. 5, pp. 517-520, May 2002.
L. B. Ware et al., “Keratinocyte and Hepatocyte Growth Factors in the Lung: Roles in Lung Development, Inflammation, and Repair”, American Journal of Physiology, vol. 282, No. 5 Part 1, pp. L924-L940, May 2002.
K. Ishizawa et al., “Hepatocyte Growth Factor Induces Angiogenesis in Injured Lungs Through Mobilizing Endothelial Progenitor Cells”, Biochemical and Biophysical Research Communications, vol. 324, No. 1, pp. 276-280, Nov. 5, 2004.
M. Dohi et al., “Hepatocyte Growth Factor Attenuates Collagen Accumulation in a Murine Model of Pulmonary Fibrosis,”Am. J Respir. Crit. Care Med. (2000), vol. 162, No. 6, pp. 2302-2307.
K. Akiyama et al., “Effect of Hepatocyte Growth Factor on Lung Injury and Development of Clinical Application,”Chest(2001), vol. 120, No. SUPPL, p. 59S.
X. Liu et al., “The protective effect of hepatocyte growth-promoting factor (pHGF) against hydrogen peroxide-induced acute lung injury in rats,”Med. Electron. Microse. (2001), vol. 34, pp. 92-102.

Affiliated with

Also associated with

Rating

Differentiation- or regeneration-inducing agent for alveoli does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Differentiation- or regeneration-inducing agent for alveoli, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Differentiation- or regeneration-inducing agent for alveoli will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4232296