Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1987-02-05
1991-11-19
Saunders, David A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
4351722, 43524027, 435948, 436503, 436548, 436811, 530350, 530387, 530395, 530806, 530809, 530827, 935110, C07K 1506, C07K 1528, G01N 33567, G01N 33577
Patent
active
050665812
ABSTRACT:
This invention provides a purified new differentiation antigen, designated NDA.sub.3, associated with the growth and proliferation of activated B lymphocytes and characterized by a molecular weight of about 36,000 daltons.
The invention also provides an antibody capable of specifically forming a complex with purified NDA.sub.3. Another aspect of the invention provides a hybridoma which produces a monoclonal antibody that specifically recognizes the isolated NDA.sub.3.
The invention also pertains to a method for detecting B cells or helper T cells, each of which has a B cell growth factor receptor, which comprises contacting a sample which contains B cells or helper T cells with substances capable of forming complexes with the B cell growth factor receptors so as to form cellular complexes between the substances and the B cell growth factor receptors, and detecting such cellular complexes.
REFERENCES:
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Roitt, Essential Immunology, 5th Ed., Blackwell Scientific Publication, Oxford, 1984, pp. 68, 70, 326 and 327.
King Donald W.
Suciu-Foca Nicole
Saunders David A.
The Trustees of Columbia University in the City of New York
White John P.
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