Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1995-03-30
1999-11-09
Kunz, Gary L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514557, A01N 3718, A01N 3702
Patent
active
059815973
ABSTRACT:
A method for decreasing the inflammation associated with a chronic inflammatory intestinal condition in a patient is provided wherein the patient is administered an effective amount of a differentiating agent.
REFERENCES:
patent: 4200647 (1980-04-01), Bollag et al.
patent: 5369108 (1994-11-01), Breslow et al.
patent: 5446035 (1995-08-01), Neef et al.
patent: 5852056 (1998-12-01), Samid
Medline Abstract 89127883, Morassi et al. Minerva Medica 80(1):65-70, 1989.
Biosis Abstract No. 91:522751, Guillemot et al., Dis Colon Rectum 34(10):861-864, 1991.
Kelly et al. Am. J. Physiol. 267:pG991-7,1994.
Barnard et al., "Localization of Tranforming Growth Factor .beta. Isoforms in the Normal Murine Small Intestine and Colon," Gastroenterolgy (1993), 105:67-73.
Biasco et al., "Proliferative and Antigenic Properties of Rectal Cells in Patients with Chronic Ulcerative Colitis," Cancer Res. (1984), 44:5450-5454.
Bikle et al., "Vitamin D, Caldium and Epidermal Differentiation," Endocrin Reviews (1993), 14(1):3-19.
Bland, P., "MHC Class Ii Expression by the Gut Epithelium," Immuno. Today (1988). 9:174-178.
Breuer et al., "Rectal Irrigation with Short-Chain Fatty Acids for Distal Ulcerative Colitis", Dig. Dis. Sci. (1991), 36:185-187.
Cao et al., "Regulated Expression of Three C/EBP Isoforms during Adipose Conversion of 3T3-L1 Cells," Genes and Develop. (1991), 5:1538-1552.
Chen, Z. and Breitman, T.R., "Tributyrin: A Prodrug of Butyric Acid for Potential Clinical Application in Differentiation Therapy", Cancer Research (1994) 54:3494-3499.
Chomczynski, P. and Sacchi, N., "Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate-Phenol-Chloroform Extraction", Anal. Biochem. (1987) 162:156-159.
Gordon, J.I, "Intestinal Epithelial Differentiation: New Insights form Chimeric and Transgenic Mice," J. Cell. Biol. (1989), 108:1187-1194.
Halline et al., "Effects of 1,25-Dihydroxyvitamin D.sub.3 on Proliferation and Differentiation of Caco-2 Cells," Endocrinology (1994), 134(4):1710-1717.
Hawkey et al.,"Therapeutic Interventions in Gastrointestinal Disease based on an Understanding of Inflammatory Mediators," Agents Actions (1992), 92:c22-26.
Huang et al. "Overexpression of a Trucated Growth Hormone Receptor in the Sex-Linked Dwarf Chicken: Evidence for a Splice Mutation", Mol. Endo. (1993), 7:1391-1398.
Izzo et al., In Situ Reverse Transcription PCR of Interleukin-8 mRNA Colonic Mucosa from Patients with Active Ulcerative Colitis, Gastroenterology (1994), 106:A705.
Larson et al., "1,25(OH).sub.2 -D.sub.3 is a Potent Regulator of Interleukin-1 Induced Interleukin-8 Expression and Production," Biochem. BIophys. Res. Comm. (1991), 176(3):1020-1026.
McDonald, T.T., "Epithelial Proliferation in Response to Gastrointestinal Inflammation," Ann. NY Acad. Sci., (1992), 664:202-209.
Marchuk et al., "Construction of T-vectors, a rapid and general systems for direct cloning of unmodified PCR products", Nuc. Acids Res. (1991), 19:1154.
Murdoch et al., "Calcipotriol: A Review of its Pharmacological Properties and Therapeutic Use in Psoriasis Vulgaris," Drugs (1992), 43(3):415-429.
Nudelman et al., "Novel Anticancer Prodrugs of Butyric Acid", J. Med. Chem. (1992), 35(4):687-694.
Planchone et al., "Differential Elimination of Synthetic Butyric Triglycerides In Vivo: A Pharmcokinetic Study", J. Pharm. Sci. (1993), 82:1046-1048.
Pols et al., "Vitamin D Analogues: From Molecule to Clinical Application," Clin. Endocrin. (1994), 40:285-291.
Radema et al., "Interleukin 1.beta. is Expressed Predominantly by Enterocytes in Experimental Colitis," Gastroenterology (1991), 100:1180-1186.
Risio, M., "Cell Proliferation in Colorectal Tumor Progression: An Immunohistochemical Approach to Intermediate Biomarkers", J. Cell Biochem. (1992), 16G:79-87.
Samid et al., "Selective Growth Arrest and Phenotypic Reversion of Prostate Cancer Cells in Vitro by Nontoxic Pharmacological Concentrations of Phenylacetate," J. Clin. Invest. (1993), 91:2288-2295.
Scheppach et al., "Effect of Butyrate Enemas on the Colonic Mucosa in Distal Ulcerative Colitis," Gastroenterology (1992), 103:51-56.
Serafini et al., "Rate and pattern of epithelial cell proliferation in ulcerative colits," Gut (1981), 22:648-652.
Snyderman et al., "The Absorption of Short-Chain Fats By Premature Infants", Arch. Dis. Child. (1955), 30:83-84.
Steinhart et al., "Treatment of Refractory Ulcerative Proctosigmoiditis with Butyrate Enemas", Am. J. Gastro. (1994), 89:179-183.
Thibault et al., "A Phase I and Pharmacokinetics Study of Intravenous Phenylacetate in Patients with Cancer," Cancer Res. (1994), 54:1690-1694.
Traber et al., "Novel DNA-Binding Proteins Regulate Intestine-Specific Transcription of the Scurase-Isomaltase Gene", Mol. Cell. Biol. 12:3614-3627, 1992.
Traber et al., "Sucrase-isomaltase gene expression along crypt-villus axis of human small intestine is regulated at level of mRNA abundance", Am. J. Physiol., 262:G123-G130, 1992.
Wu et al., "Sucarse-Isomaltase Gene Expression in Barrett's Esophagus and Adenocarcinoma", Gastroenterology (1993), 105:837-844.
Wu et al., "Isolation and Characterization of the Human Scurase-Isomaltase Gene and Demonstrationl of Intestine-Specific Transcriptional Elements," J. Biol. Chem. 267:7863-7870, 1992.
Kunz Gary L.
Trustees of the University of Pennsylvania
LandOfFree
Differentiating agents for the treatment of inflammatory intesti does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Differentiating agents for the treatment of inflammatory intesti, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Differentiating agents for the treatment of inflammatory intesti will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1456866