Differential inactivation of nucleic acids by chemical modificat

Details Differential inactivation of nucleic acids by chemical modificat Differential inactivation of nucleic acids by chemical modificat

1996-01-19

1998-12-01

Ketter, James

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

435 703, 4353201, 4351733, 435 5, 424 932, C12Q 170, A61K 39245

Patent

active

058434593

ABSTRACT:
Disclosed herein is the method for dramatically reducing cytotoxicity of viral vectors such as Herpes simplex viral while retaining gene expression. The method of the invention virtually eliminates the concern of possible recombination during virus propagation and contamination of wild-type virus and virus stock. The invention comprises use of photochemical crosslinking causing differential inactivation of viruses.

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