Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1996-07-29
1998-10-27
Horlick, Kenneth R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
435 6, 435 912, C12Q 170, C12Q 168, C12P 1934
Patent
active
058276483
ABSTRACT:
This invention relates to a method of measuring the relative populations of first and second variants of a target nucleotide sequence of a target genome in a sample utilizing an amplification step, followed by probing with first and second variant probes and a control probe. Specific embodiments include an assay to monitor the conversion of codon 215 for HIV-1 reverse transcriptase from wild type to mutant form.
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Gingeras et al. Jour. Infect. Dis. 164: 1066-1074, 1991.
Rudert et al. Nuc. Acids Reg. 20(5): 1106, 1992.
Eastman P. Scott
Kolberg Janice A.
Urdea Michael S.
Blackburn Robert P.
Chiron Corporation
Goldman Kenneth M.
Horlick Kenneth R.
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