Differential diagnosis of cancer and other conditions based...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S006120, C436S064000, C436S501000, C436S518000

Reexamination Certificate

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06972181

ABSTRACT:
This invention relates to methods of distinguishing among various types of differentiated and undifferentiated epithelial carcinomas, and non-epithelial carcinomas, by detecting the presence of p63 nucleic acid or protein expression. The invention also provides methods for detecting p63 nucleic acids and proteins, as well as methods for diagnosing and treating certain tumors based on whether the tumors express p63.

REFERENCES:
HiBi et al., (2000, Proc. Natl. Acad. Sci. USA., vol. 97, pp. 5462-5467).
Syllabus with the title “Pathology of Lung Cancer” downloaded on Dec. 9, 2004 from url>>http://www.metrohelath.org/clinical/pathology/syllabus/carcinoma.asp, pp. 1-11.
OMIM with #603273 (note p. 1, first paragraph) downloaded on Dec. 10, 2004 from url>>www.ncbi.nlm.nih.go.
Wu et al., (2003, Cancer Research, vol. 63, pp. 2351-2357).
Wang et al., (2002, Hum. Pathol. vol. 33, pp. 921-926).
Hall et al., Carcinogenesis 2000; 21: 53-60.
Parsa et al., J. Invest. Dermatol. 1999; 113:1099-1105.
Yamaguchi et al., Int. J. Cancer 2000; 86:684-89.
Levrero et al., J. Cell Science 2000; 113:1661-70.

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