Dietary compositions and methods using bile salt-activated lipas

Details Dietary compositions and methods using bile salt-activated lipas Dietary compositions and methods using bile salt-activated lipas

1987-11-19

1990-07-31

Stone, Jacqueline

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424535, 426 2, 426580, 426588, 426801, A61K 3754, A23C 900, A23L 238

Patent

active

049449443

ABSTRACT:
Dietary compositions, especially cow's milk-based infant formulas, are fortified with bile salt-activated lipase. Methods are provided for feeding newborn and premature infants which include administration of bile salt-activated lipase to increase fat digestion and therefore growth rate. Similarly, a method is provided to treat subjects for inadequate pancreatic enzyme production by administration of bile salt-activated lipase in conjunction with ingestion of fats.

REFERENCES:
Hernell, "Human Milk Lipases", Europ. J. Clin. Invest. 5, 267-272 (1975).
S. Williamson, et al., Arch. Dis. Child., 53, 555-563, 1978, "Effect of Heat Treatment of Human Milk on Absorption of Nitrogen, Fat, Sodium, Calcium, and Phosphorus by Preterm Infants".
C. Wang, J. Biol. Chem., 256:10198-10202, 1981, "Human Milk Bile Salt-Activated Lipase".
B. Alemi, et al., Pediatrics, 68:484-489, 1981, "Fat Digestion in Very Low-Birth-Weight Infants: Effect of Addition of Human Milk to Low-Birth-Weight Formula".
C. Wang, et al., Anal. Biochem., 133:457-461, 1983, "Purification of Human Milk Bile Salt-Activated Lipase".
C. Wang, et al., Biochim. Biophys. Acta, 754:142-149, 1983, "Kinetic Properties of Human Pancreatic Carboxylesterase".
C. Wang, ed., Fat Adsorption, vol. 1, CRC Press, 1986, Chapter 3, "Hydrolysis of Dietary Glycerides and Phosphoglycerides: Fatty Acid and Positional Specificity of Lipases and Phospholipases".
C. Wang, et al., J. Lipid Res., 26:824-830, 1985, "Kinetic Properties of Human Milk Bile Salt-Activated Lipase: Studies Using Long Chain Triacylglycerol as Substrate".
L. Freed, et al., Biochim. Biophys. Acta, 878:209-215, 1986, "Bile Salt-Stimulated Lipase in Non-Primate Milk: Longitudinal Variation and Lipase Characteristics in Cat and Dog Milk".

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