Dietary and hormonal regulation of expression of exogenous genes

Details Dietary and hormonal regulation of expression of exogenous genes Dietary and hormonal regulation of expression of exogenous genes

1988-06-13

1991-12-24

Weimar, Elizabeth C.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

514 44, 800 2, 800DIG2, 935 62, 935111, C12N 1500, A61K 4800

Patent

active

050752294

ABSTRACT:
A transgenic animal is constructed in which one or more cells contain a promoter to the gene for cytosolic PEPCK operably linked to a non-PEPCK gene of interest. Expression of this gene is controlled by modifying the protein and carbohydrate components of the animal's diet, or by direct hormonal regulation. The PEPCK promoter is induced by high protein and inhibited by high carbohydrate, or more directly by cAMP and insulin. The linked gene is expressed essentially only after bith and essentially only in particular tissues. The PEPCK promoter has a extremely high promoter strength.

REFERENCES:
patent: 4579821 (1986-04-01), Palmiter et al.
patent: 4736866 (1988-04-01), Leder et al.
Ornitz et al., Nature 313: 600-602 (1985).
Hursar et al., Proc. Natl. Acad. Sci. 82: 8587-8591 (1985).
Wilmut et al., New Scientist, Jul. 7, 1988, pp. 56-59.
Van Brunt, Biotechnology 6(10): 1149-1154 (1988).
Weiss et al., RNA Tumor Viruses: Molecular Biology of Tumor Viruses, 2d Ed., Table 2S.1, "Retroviruses", Cold Spring Harbor, 1985.
Hatzoglou et al., Hepatic Gene Transfer in Animals using Retroviruses . . . , The Journal of Biological Chemistry, vol. 265, No. 28, pp. 17285-17293, Oct. 1990.
Wynshaw-Borris et al. (I), J. Biol. Chem. 261(21): 9714-9720 (1986).
Wynshaw-Borris et al. (II), J. Biol. Chem. 259(19): 12161-12169 (1984).
Andres et al. (I), Proc. Natl. Acad. Sci. 84: 1299-1303 (1987).
Andres et al. (II), Experientia 42: 673 (1986).

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