Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1991-03-27
1992-12-08
Griffin, Ronald W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 8, 514929, 514 54, 514908, 536 2, 536 3, 536 20, 536127, 536114, 536123, 435 891, 424 852, A61K 3012, C12R 191, C12R 500, C12R 502
Patent
active
051698404
ABSTRACT:
The present invention is directed to a material and method for the stimulation of the production of cytokines. Several polysaccharides, including polymers of different size of .sym.1-4 linked D-mannuronic acid (poly-M and M-blocks), chitosan and cellulose oxidized in C-6 position C60XY) induce human monocytes to produce the cytokines. Preferably, the molecular weights of poly-M and chitosan are above 50,000 and 20,000 respectively. Pretreatment of the monocytes with IFN-.gamma. increases the cytokine production from monocytes stimulated with all polysaccharides tested. The subject polysaccharides worked in vivo and in vitro.
The present invention has therapeutic utility as vaccine adjuvants and components. Therapeutic compositions comprising biologically active quantities of the compositions of the present invention may be employed to potentiate antibody production in response to vaccine antigens. Anti-tumor, anti-bacteriological, anti-fungal and anti-viral effects may be expected.
REFERENCES:
patent: 4578458 (1986-03-01), Pier
patent: 4605623 (1986-08-01), Malette et al.
patent: 4840941 (1989-06-01), Ueno et al.
patent: 4963354 (1990-10-01), Shepard et al.
patent: 4965271 (1990-10-01), Mandell et al.
patent: 5002759 (1991-03-01), Gaffar et al.
Painter et al.; Carbohydrates Research, 140 (1985) 61-68; "New Gluco-noglucans Obtained by Oxidation of Amylose at Position 6".
Skjak-Braek et al.; Carbohydrate Research, 154 (1986) 239-250; "Monomer Sequence & Acetylation Pattern In Some Bacterial Alignates".
Browning et al.; Journal of Immunology; 138(9), 2857-63; "Interferon Blocks Interleukin 1-induced Prostaglandin Release From Human Peripheral Monocytes".
Holter et al.; Journal of Immunology; 138(9), 2917(22); "Expression of Functional IL-2 Receptors by Lipolysaccharides and Interferron-.gamma.Stdm Human Monocytes".
Espevik Terje
Otterlei Marit
Skjak-Brock Gudmund
Smidsrod Olav
Griffin Ronald W.
Nobipols Forskningsstiftelse
Protan Biopolymer A/S
LandOfFree
Diequatorially bound .beta.-1, 4 polyuronates and use of same fo does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Diequatorially bound .beta.-1, 4 polyuronates and use of same fo, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diequatorially bound .beta.-1, 4 polyuronates and use of same fo will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-961115