Diene derivatives and vasodilators containing the same

Details Diene derivatives and vasodilators containing the same Diene derivatives and vasodilators containing the same

1987-02-03

1988-12-20

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544396, A61K 31495, C07D29506

Patent

active

047925531

ABSTRACT:
Novel dienyl derivatives are disclosed. As examples of said diene derivative are mentioned 1-benzhydryl-4-(5-phenyl-2,4-pentadienyl)piperazine, 1-(4,4'-difluorobenzhydryl)-4-(5-phenyl-2,4-pentadienyl)piperazine, 1-benzhydryl-4-(5-(3,4,5-trimethoxyphenyl)-2,4-pentadienyl)piperazine, 1-(4,4'-difluorobenzhydryl)-4-(5-(2,4-dimethoxyphenyl)-2,4-pentadienyl)pip erazine, 1-benzhydryl-4-(5-(2,3,4-trimethoxyphenyl)-2,4-pentadienyl)piperazine, 1-(4,4'-difluorobenzhydryl)-4-(5-(2,3,4-trimethoxyphenyl)-2,4-pentadienyl) piperazine and the like. These dienyl derivatives are useful as vasodilators.

REFERENCES:
patent: 4663325 (1987-05-01), Ohtaka et al.
Takai et al., Chemical Abst. 106-156495h.

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