Diels-alder adduct from streptazoline and naphthoquinones and it

Details Diels-alder adduct from streptazoline and naphthoquinones and it Diels-alder adduct from streptazoline and naphthoquinones and it

1987-05-12

1989-07-18

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 63, 514279, 536 174, 546 14, 546 41, A61K 3147, C07D49806

Patent

active

048494097

ABSTRACT:
Streptazoline is reacted with naphthoquinones in a Diels-Alder reaction, and the adduct is then oxidized. The resulting compounds have cytotoxic activity, in particular against leukemia cells, and have an antimicrobial action and act against protozoa.

REFERENCES:
Grabley, et al., Angew. Chem., vol. 99(7), pp. 692-693 (1987).
Drautz, et al., Chemical Abstracts, vol. 96:16990r (1982).
Kozikowski, et al., J. Am. Chem. Soc., vol. 107(6), pp. 1763-1765 (1985).
Fuson, "Reactions of Organic Compounds", John Wiley & Sons, Inc. New York (1962) pp. 683-685, 697.
A. Karrer and M. Dobler, "X-Ray Analysis of O-Acetyl Dihydro-Strepatzoline", Helv. Chim. Acta, vol. 65 (5) 1432-1435 (1982).

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