Dideoxynucleoside derivatives

Details Dideoxynucleoside derivatives Dideoxynucleoside derivatives

2007-02-26

2009-12-08

Crane, Lawrence E (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S026700, C536S026800, C536S027600, C536S027810, C536S028500, C536S028530

Reexamination Certificate

active

07629447

ABSTRACT:
The invention provides a 5′-amino-2′-fluoro-2′,5′-dideoxynucleoside compound represented by the formula [1]:wherein R1represents a nucleic acid base which may have a protecting group; R2represents a hydrogen atom or an amino protecting group; and R3represents a hydrogen atom or a hydroxyl protecting group. The invention also provides a dideoxynucleoside-insoluble carrier bound substance and an oligonucleotide analogue involving the dideoxynucleoside compound.

REFERENCES:
patent: 4851519 (1989-07-01), Lambert et al.
patent: 5010060 (1991-04-01), Lambert et al.
patent: WO 03/093472 (2003-11-01), None
(R) Harada et al., “Nucleosides. 139. Synthesis and Anticytomegalovirus and Antiherpes Simplex Virus Activity of 5′-Modified Analogues of 2′-Fluoroarabinosylpyrimidine Nucleosides,” Journal of Medicinal Chemistry, 30(1), 226-229 (1987).
Gryaznov et al.,Nucleic Acids Research, 20(13): 3403-09 (1992).
Helmling et al.,Nucleosides, Nucleotides&Nucleic Acids, 22(5-8): 1035-38 (2003).
Kawasaki et al.,J. Med. Chem., 36(7): 831-41 (1993).
Obika et al.,Angewandte Chemie International Edition, 44(13): 1944-47 (Mar. 18, 2005).
Obika et al.,Chem. Commun., 2202-03 (2003).
Shi et al.,Bioorganic&Medicinal Chemistry, 13: 1641-52 (2005).
Ueno et al., The Chemical Society of Japan 86th Spring Convention, Abstract No. 2G3-38 (Mar. 13, 2006).
Kawasaki et al.,J. Med. Chem., 36: 831-41 (1993).
Ueno et al.,J. Org. Chem., 70: 7925-35 (2005).
Ueno et al.,Tetrahedron, 64: 11328-34 (2008).

Affiliated with

Also associated with

Rating

Dideoxynucleoside derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Dideoxynucleoside derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dideoxynucleoside derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4071747