Dideoxyinosine by enzymatic deamination of dideoxyadenosine

Details Dideoxyinosine by enzymatic deamination of dideoxyadenosine Dideoxyinosine by enzymatic deamination of dideoxyadenosine

1990-02-28

1991-04-30

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 88, 435183, 435188, 435227, 435280, C12P 1938, C12P 1940, C12N 996, C12N 978

Patent

active

050117742

ABSTRACT:
A novel process utilizing adenosine deaminase to selectively produce .beta.-(D)-2',3'-dideoxyinosine in high yields from an .alpha.,.beta.-anomeric mixture. .beta.-(D)-2',3'-Dideoxyinosine so produced is useful as an antiviral and antibiotic agent.

REFERENCES:
Rosemeyer et al., Eur. J. Biochem. 122:375-380 (1982).
Prisbe et al., Synth. Communications, 15, 401 (1985) (1/11).
Webb et al., Nucleosides and Nucleotides, 7, (2), 147-143 (1988).

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