Dideoxycarbocyclic nucleosides

Organic compounds -- part of the class 532-570 series – Organic compounds – Pteroyl per se or having -c- – wherein x is chalcogen – bonded...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

544277, A61K 3152

Patent

active

060720530

ABSTRACT:
A therapeutic method is provided, employing an antiviral compound of the general formula: ##STR1## wherein Z is H, OR' or N(R).sub.2, wherein R' is H, (C.sub.1 -C.sub.4)alkyl, aryl, CHO, (C.sub.1 -C.sub.16)alkanoyl or O.dbd.P(OH).sub.2, Y is CH or N, and X is selected from the group consisting of H, N(R).sub.2, SR, OR' or halogen, wherein R is H, lower (C.sub.1 -C.sub.4)alkyl, aryl or mixtures thereof, and the pharmaceutically acceptable salts thereof.

REFERENCES:
patent: 3775397 (1973-11-01), Etzold et al.
patent: 3817982 (1974-06-01), Verhaden et al.
patent: 3917837 (1975-11-01), Lin et al.
patent: 4076711 (1978-02-01), Ganguly et al.
patent: 4115438 (1978-09-01), Woessner
patent: 4138562 (1979-02-01), Vince
patent: 4223156 (1980-09-01), Vince
patent: 4268672 (1981-05-01), Vince
patent: 4362729 (1982-12-01), Vince
patent: 4383114 (1983-05-01), Vince
patent: 4543255 (1985-09-01), Shealy et al.
patent: 4636383 (1987-01-01), Nagabhushan et al.
patent: 4710492 (1987-12-01), Lin
patent: 4724232 (1988-02-01), Rideout et al.
patent: 4742064 (1988-05-01), Vince
patent: 4859677 (1989-08-01), Borchardt et al.
patent: 4880782 (1989-11-01), Eckstein et al.
patent: 4916122 (1990-04-01), Chu et al.
patent: 4916224 (1990-04-01), Vince et al.
patent: 4931559 (1990-06-01), Vince et al.
patent: 4950758 (1990-08-01), Vince et al.
patent: 4968674 (1990-11-01), Taniyama et al.
patent: 4999428 (1991-03-01), Saksena et al.
patent: 5034394 (1991-07-01), Daluge
patent: 5049671 (1991-09-01), Daluge
patent: 5087697 (1992-02-01), Daluge
patent: 5089500 (1992-02-01), Daluge
patent: 5122517 (1992-06-01), Vince et al.
patent: 5175292 (1992-12-01), Vince et al.
patent: 5808147 (1998-09-01), Daluge et al.
patent: 5840990 (1998-11-01), Daluge et al.
Lin, T.S., et al., "Antiviral Activity of 2', 3'-Dideoxycytidin-2'-ene (2',3'-Dideoxy-2',3'-didehydrocytidine) Against Human Immunodeficiency Virus In Vitro", Biochemical Pharmacology, 36, 311-316 (1987).
Lin, T.S., et al., "Synthesis and Antiviral Activity of Various 3'-Azido, 3'-Amino, 2',3'-Unsaturated, and 2',3'-Dideoxy Analogues of Pyrimidine Deoxyribonucleosides against Retroviruses", Journal of Medicinal Chemistry, 30, 440-444 (1987).
Mitsuya, H., et al., "Rapid in Vitro Systems for Assessing Activity of Agents Against HTLV-III/LAV", In: AIDS--Modern Concepts and Therapeutic Challenges, Broder, S., (ed.), Marcel Dekker, Inc., New York, 303-333 (1987).
Vince, R., "Carbocyclic Nucleoside Chemotherapeutic Agents", Notice of Grant Award, Department of Health, Education and Welfare--Public Health Service, Awarded by The National Cancer Institute, Grant No. 1 R01 CA23263-01A1, 37 p. (Issued Feb. 21, 1979).
Vince, R., "Carbocyclic Nucleoside Chemotherapeutic Agents", Notice of Grant Award, Department of Health, Education and Welfare--Public Health Service, Awarded by The National Cancer Institute, Grant No. 5 R01 CA23263-02, 6 p. (Issued Dec. 10, 1979).
Vince, R., "Carbocyclic Nucleoside Chemotherapeutic Agents", Notice of Grant Award, Department of Health, Education and Welfare--Public Health Service, Awarded by The National Cancer Institute, Grant No. 5 R01 CA23263-03, 6 p. (Issued Dec. 31, 1980).
Vince, R., "Carbocyclic Nucleoside Chemotherapeutic Agents", Notice of Grant Award, Department of Health, Education and Welfare--Public Health Service, Awarded by The National Cancer Institute, Grant No. 2 R01 CA23263-04A1, 44 p. (Issued Apr. 11, 1983).
Vince, R., "Carbocyclic Nucleoside Chemotherapeutic Agents", Notice of Grant Award, Department of Health and Human Services--Public Health Service, Awarded by The National Cancer Institute, Grant No. 5 R01 CA23263-05, 8 p. (Issued Dec. 15, 1983).
Vince, R., "Carbocyclic Nucleoside Chemotherapeutic Agents", Notice of Grant Award, Department of Health and Human Services--Public Health Service, Awarded by The National Cancer Institute, Grant No. 5 R01 CA23263-06, 10 p. (Issued May 22, 1986).
Vince, R., "Carbocyclic Nucleoside Chemotherapeutic Agents", Notice of Grant Award, Department of Health and Human Services--Public Health Service, Awarded by The National Cancer Institute, Grant No. 2 R01 CA23263-07, 34 p. (Issued May 22, 1986).
Vince, R., "Carbocyclic Nucleoside Chemotherapeutic Agents", Notice of Grant Award, Department of Health and Human Services--Public Health Service, Awarded by The National Cancer Institute, Grant No. 5 R01 CA23263-08, 8 p. (Issued Jun. 19, 1987).
Vince, R., "Carbocyclic Nucleoside Chemotherapeutic Agents", Application for Continuation Grant, Department of Health and Human Services--Public Health Service, Grant No. 5 R01 CA23263-06, 9 p., (Appvd. Dec. 14, 1984).
Vince, R., "Carbocyclic Nucleoside Chemotherapeutic Agents", Notice of Grant Award, Department of Health, Education and Welfare--Public Health Service, Awarded by the National Cancer Institute, Grant No. 5 R01 CA23263-02, 26 p. (Issued Jun. 13, 1980).
Bajorek, J.J., et al., "A Modified Prins Reaction Applicable to Conjugated Dienes", Journal of the Chemical Society, 11, 1243-1245, (1974).
Chaudhary, S.K., et al., "A Simplified Procedure for the Preparation of Triphenylmethylethers", Tetrahedron Letters, No. 2, 95-98, (1979).
Connolly, K.J., et al., "Antiretroviral Therapy: Reverse Transcriptase Inhibition", Antimicrobial Agents and Chemotherapy, 36, 245-254, (Feb. 1992).
Daluge, S.M., et al., "1592U89 Succinate--A Novel Carbocyclic Nucleoside Analog with Potent, Selective Anti-HIV Activity", Anti-HIV Agent 1592U89 Succinate--Presentations at the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy, Abstract I6, Orlando, FL, 2 p., (Oct. 4-7, 1994).
Faletto, M.B., et al. "Unique Intracellular Activation of a New Anti-HIV Agent (1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-me thanol (1592U89) in the Human T-Lymphoblastoid Cell Line CEM-T4", Anti-HIV Agent 1592U89 Succinate--Presentations at the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy, Abstract I84, Orlando, FL, 3 p., (Oct. 4-7, 1994).
Iwakawa, M., et al., "Synthetic Routes to Nucleoside Analogs of N-substituted 1,3-thiazolidines", Canadian Journal of Chemistry, 56, 326-335, (Feb. 1, 1978).
Marquez, V.E., et al., "Synthesis of 2',3'-dideoxycyclopentenyl Carbocyclic Nucleosides as Potential Drugs for the Treatment of AIDS", Nucleosides & Nucleotides, 6, 239-244, (1987).
Matsumura, Y., et al., "Preparation of Cyclopentene Ring-Containing Nucleosides as Drugs", Chemical Abstracts, 111, Abstract No. 39839r, p. 650, (1989).
Mitsunobu, O., "The Use of Diethyl Azodicarboxylate and Triphenylphosphine in Synthesis and Transformation of Natural Products", Synthesis, 1-28, (Jan. 1981).
Saunders, J., "Non-nucleoside Inhibitors of HIV Reverse Transcriptase: Screening Successes--Clinical Failures", Drug Design and Discovery, 8, 255-263, (1992).
Szarek, W.A., et al., "Synthesis of Nucleosides by Direct Replacement of the Anomeric Hydroxy-group", Journal of The Chemical Society, 15, 648-649, (1975).
Chemical Abstracts, 165109f, 86, 20, (1977).
Chemical abstracts, 187143h, 99, 33, (1983).
Chemical Abstracts, 4203g, 94, 395, (1981).
"WPI Accession No. 89-071674/10, Abstract of 1022853", published Jan. 25, 1989, claiming priority from JP 87177234 dated Jul. 17, 1987.
Baba, et al., "Biochem Biophys Res. Comm.", Biochem Biophys Res. Comm., 142, 128, (1987).
Balzarini, et al., "Biochem Biophys. Res. Comm.", Biochem Biophys. Res. Comm., 140, 735, (1986).
Balzarini, et al., "Biochem Pharmacol.", Biochem Pharmacol, 37, 2847, (1988).
Balzarini, et al., "Molec. Pharmacol", Molec. Pharmacol, 32, 162, (1987).
Baum, R.M., C&EN, Dec. 1, 7-12, (1986).
Brouwer, K.R., et al., Drug Metabolism and Disposition, 18, 1078, (1990).
Carter, S.G., et al., Antimicrobial Agents and Chemotherapy, 34, 1297, (1990).
Chu, et al., "Biochem Pharmacol", Biochem Pharmacol, 37, 3543, (1988).
Coward, et al., "J. Med. Chem.", J. Med. Chem., 16, 460, (1973).
Dagani, R., C&EN, Dec. 8, 7-14, (1986).
Dagani, R., C&EN, Jun. 29, 25-27i, (1987).
Davoll, J., "A synthesis of crotonoside", J. of Am. Chem. Soc., 73, 3174, (1951).
DeClercq, E., J. Med. Chem., 29, 1561-1569, (1986).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Dideoxycarbocyclic nucleosides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Dideoxycarbocyclic nucleosides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dideoxycarbocyclic nucleosides will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2214590

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.