Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2011-08-16
2011-08-16
Andres, Janet L (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C514S369000
Reexamination Certificate
active
07999114
ABSTRACT:
This invention relates to dicycloalkylcarbamoyl ureas of formula (I), which are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.
REFERENCES:
patent: 3067250 (1962-12-01), Oja
patent: 3152136 (1964-10-01), Harris et al.
patent: 3317534 (1967-05-01), Nitta et al.
patent: 3551442 (1970-12-01), Guillot et al.
patent: 3734923 (1973-05-01), Dowding et al.
patent: 3862163 (1975-01-01), Boroschewski et al.
patent: 3874873 (1975-04-01), Volpp et al.
patent: 3887709 (1975-06-01), Brzozowski et al.
patent: 3967950 (1976-07-01), Kano et al.
patent: 4153710 (1979-05-01), Brzozowski et al.
patent: 4160833 (1979-07-01), Diel
patent: 4174398 (1979-11-01), Regel et al.
patent: 4175081 (1979-11-01), Driscoll
patent: 4183856 (1980-01-01), Makisumi et al.
patent: 4241072 (1980-12-01), Bolhofer
patent: 4243404 (1981-01-01), Kruger et al.
patent: 4405644 (1983-09-01), Kabbe et al.
patent: 4694004 (1987-09-01), Nakaguti et al.
patent: 4808722 (1989-02-01), Henrie
patent: 5262415 (1993-11-01), Takemoto et al.
patent: 5371086 (1994-12-01), Takemoto et al.
patent: 5556969 (1996-09-01), Chambers et al.
patent: 5846985 (1998-12-01), Murugesan
patent: 5846990 (1998-12-01), Murugesan et al.
patent: 5849732 (1998-12-01), Suzuki et al.
patent: 5849769 (1998-12-01), Lind et al.
patent: 5891917 (1999-04-01), Tang et al.
patent: 5935993 (1999-08-01), Tang et al.
patent: 6001860 (1999-12-01), Hamanaka
patent: 6140343 (2000-10-01), DeNinno et al.
patent: 6180635 (2001-01-01), Cheshire et al.
patent: 6225346 (2001-05-01), Tang et al.
patent: 6268384 (2001-07-01), Novak et al.
patent: 6271248 (2001-08-01), Murugesan et al.
patent: 6384220 (2002-05-01), Corbett et al.
patent: 6448290 (2002-09-01), Ohuchuida et al.
patent: 6486184 (2002-11-01), Kester et al.
patent: 6489478 (2002-12-01), DeNinno et al.
patent: 6500817 (2002-12-01), Fischer et al.
patent: 6559168 (2003-05-01), Marfat et al.
patent: 6608218 (2003-08-01), Kester et al.
patent: 6720347 (2004-04-01), Rawlins et al.
patent: 6720427 (2004-04-01), Sanner et al.
patent: 6784198 (2004-08-01), Pevarello et al.
patent: 6863647 (2005-03-01), Pevarello et al.
patent: 6875760 (2005-04-01), Lau et al.
patent: 6903125 (2005-06-01), Kontani et al.
patent: 6916814 (2005-07-01), Moss et al.
patent: 6936629 (2005-08-01), Chan Chun Kong et al.
patent: 7056942 (2006-06-01), Hildesheim et al.
patent: 7196104 (2007-03-01), Askew et al.
patent: 7384967 (2008-06-01), Polisetti et al.
patent: 7582769 (2009-09-01), Murray et al.
patent: 2002/0198200 (2002-12-01), Kester et al.
patent: 2003/0171411 (2003-09-01), Kodra et al.
patent: 2003/0220350 (2003-11-01), Lau et al.
patent: 2004/0014789 (2004-01-01), Lau et al.
patent: 2004/0014968 (2004-01-01), Bizzarro et al.
patent: 2007/0054897 (2007-03-01), Murray et al.
patent: 2009/0216013 (2009-08-01), Murray et al.
patent: 29937 (1972-12-01), None
patent: 2416229 (2007-09-01), None
patent: 100506807 (2009-07-01), None
patent: 1901501 (1969-08-01), None
patent: 2040580 (1971-04-01), None
patent: 2117807 (1971-10-01), None
patent: 2129418 (1971-12-01), None
patent: 2228890 (1972-12-01), None
patent: 2151766 (1973-04-01), None
patent: 2431801 (1975-01-01), None
patent: 2264983 (1975-10-01), None
patent: 2712630 (1978-09-01), None
patent: 0129408 (1984-12-01), None
patent: 0432040 (1991-06-01), None
patent: 0885890 (1998-12-01), None
patent: 0979823 (2000-02-01), None
patent: 1211246 (2002-06-01), None
patent: 1169312 (2004-10-01), None
patent: 7.428 (1968-05-01), None
patent: 2001083 (1969-09-01), None
patent: 2215967 (1974-08-01), None
patent: 771147 (1957-03-01), None
patent: 1185540 (1968-11-01), None
patent: 1185540 (1970-03-01), None
patent: 1195672 (1970-06-01), None
patent: 1282308 (1972-07-01), None
patent: 1318291 (1973-05-01), None
patent: 0200396 (2002-07-01), None
patent: 01056660 (1989-03-01), None
patent: 64056660 (1989-03-01), None
patent: 4334374 (1992-11-01), None
patent: 6-16621 (1994-01-01), None
patent: 6102611 (1994-04-01), None
patent: 2002-536056 (2002-10-01), None
patent: 2021258 (1994-10-01), None
patent: WO 91/04027 (1991-04-01), None
patent: WO 93/24458 (1993-12-01), None
patent: WO 94/14801 (1994-07-01), None
patent: WO 97/24328 (1997-07-01), None
patent: WO 99/24035 (1999-05-01), None
patent: WO 99/24416 (1999-05-01), None
patent: WO 99/32106 (1999-07-01), None
patent: WO 99/32111 (1999-07-01), None
patent: WO 99/62890 (1999-12-01), None
patent: WO 00/17165 (2000-03-01), None
patent: WO 00/26186 (2000-05-01), None
patent: WO 00/26203 (2000-05-01), None
patent: WO 00/45742 (2000-08-01), None
patent: WO 00/53591 (2000-09-01), None
patent: WO 00/58293 (2000-10-01), None
patent: WO 00/58293 (2000-10-01), None
patent: WO 01/00206 (2001-04-01), None
patent: WO 01/44216 (2001-06-01), None
patent: WO 01/44217 (2001-06-01), None
patent: WO 01/57008 (2001-08-01), None
patent: WO 01/83465 (2001-11-01), None
patent: WO 01/83478 (2001-11-01), None
patent: WO 01/85706 (2001-11-01), None
patent: WO 01/85707 (2001-11-01), None
patent: WO 02/08209 (2002-01-01), None
patent: WO 02/14311 (2002-02-01), None
patent: WO 02/46173 (2002-06-01), None
patent: WO 02/070494 (2002-09-01), None
patent: WO 03/055482 (2003-07-01), None
patent: WO 03/070727 (2003-08-01), None
patent: WO 2004/002481 (2004-01-01), None
patent: WO 2004/085388 (2004-10-01), None
patent: WO 2005/066145 (2005-07-01), None
patent: WO 2005/103050 (2005-11-01), None
patent: WO 2007/006814 (2007-01-01), None
patent: WO 2008/084043 (2008-07-01), None
patent: WO 2008/084044 (2008-07-01), None
Hcaplus 1969:444446, (Nov. 5, 1968).
Hcaplus 1980:585914, “Acylcarbodiimides. IV. Preparation and some reactions of carbamoylcarboiimides”, Goerdeler, et. al., 1980.
Colowick, S. P., “The Hexokinases”, The Enzymes, 1973, vol. 9, pp. 1-48.
Chipkin, S. R. et al., “Hormone-Fuel Interrelationships: Fed State, Starvation, and Diabetes Mellitus”, Joslin's Diabetes, 1994, pp. 97-115.
Printz, R. L. et al., “Mammalian Glucokinase”, Annual Review of Nutrition, 1993, vol. 13, pp. 463-496.
Meglasson, M. D. et al., “New Perspectives on Pancreatic Islet Glucokinase”, American Journal of Physiology, 1984, vol. 246, pp. E1-E13.
Grupe, A. et al., “Transgenic Knockouts Reveal a Critical Requirement for Pancreatic β Cell Glucokinase in Maintaining Glucose Homeostasis”, Cell, 1995, vol. 83, pp. 69-78.
Ferre, T. et al., “Evidence From Transgenic Mice that Glucokinase is Rate Limiting for Glucose Utilization in the Liver”, The Faseb Journal, 1996, vol. 10, pp. 1213-1218.
Liang, Y. et al., “Variable Effects of Maturity-Onset-Diabetes-of-Youth (MODY)-associated Glucokinase Mutations on Substrate Interactions and Stability of the Enzyme”, Biochem. J., 1995, vol. 309, pp. 167-173.
Glaser, B. et al., “Familial Hyperinsulinism Caused by an Activating Glucokinase Mutation”, The New England Journal of Medicine, 1998, vol. 338, pp. 226-230.
Mann, G. V., “The Influence of Obesity on Health”, The New England Journal of Medicine, 1974, vol. 291, pp. 226-232.
“Health Implications of Obesity”, National Institutes of Health Consensus Development Conference Statement, Annals of Internal Medicine, 1985, vol. 103, pp. 147-151.
Mylari, B. L. et al., “Design and Synthesis of a Novel Family of Triazine-Based Inhibitors of Sorbitol Dehydrogenase with Oral Activity: 1-{4-[3R,5S-Dimethyl-4-(4-methyl-[1,3,5]triazin-2-yl)-piperazin-1-y1]-[1,3,5]triazin-2-yl}-(R) Ethanol”, Bioorganic & Medicinal Chemistry, 2003, vol. 11, pp. 4179-4188.
Atwal et al., 1996, “Cardioselective Antiischemic ATP-Sensitive Potassium Channel Openers 4 Structure-Activity Studies on Benzopyranylcyanoguanidines: Replacement of the Benzopyran Portion,” Journal of Medicinal Chemistry 39:304-313.
Castelhano et al., 2005, “Glucokinase-Activating Ureas,” Bioorganic & Medicinal Chemistry Letters 15:1501-1504.
Decombe, 1932,
Jeppesen Lone
Kristiansen Marit
Lau Jesper
Murray Anthony
Vedso Per
Andres Janet L
Novo Nordisk A S
Reese Heidi
Wilk-Orescan Rosemarie R.
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