Drug – bio-affecting and body treating compositions – Dentifrices
Patent
1995-06-02
1997-02-11
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Dentifrices
424 55, A61K 716, A61K 724
Patent
active
056018045
ABSTRACT:
Dicitrate cyclic diester (dicitrate) is a novel compound which is found in patients who do not exhibit symptoms or predisposition to idiopathic renal calculous disease. Dicitrate can be isolated and detected by novel chromatographic methods. Further, treating patients prophylactically and therapeutically with dicitrate cyclic diester can prevent or reduce the effects of calcification-related disease, including some types of kidney stones, or other disease or condition associated with the presence of metal ions. The metal ion complexing properties exhibited by dicitrate are also applicable to the use of the subject compounds as chelating agents and methods of binding, and thereby reducing, the amounts of metal ions in a substance.
REFERENCES:
patent: 4399003 (1983-08-01), Sarig et al.
patent: 4814177 (1989-03-01), Walsdorf et al.
patent: 4851221 (1989-07-01), Pak et al.
patent: 4888182 (1989-12-01), Pak
patent: 5075499 (1991-12-01), Walsdorf et al.
patent: 5137722 (1992-08-01), Costello
patent: 5376553 (1994-12-01), Thomas et al.
Boyce, W. H. (1979) "Epidemiology of Lithiasis in the United States" XVIIIth C. M. Congress of the International Society of Urology, Paris, Kongressbericht, Tome 1, p. 79-86.
Sierakowski, R. et al. (1978) "The Frequency of Urolithasis in Hospital Discharge Diagnoses in the United States" Investigative Urology 15(6):438-441.
Thomas, W. C. Jr. (1976) "Renal Calculi: A Guide to Management", Charles C. Thomas, Publisher, Springfield, IL, 177 pages.
Davis, George K. et al. (1974) "Urolithiasis", Geochemistry and the Environment, National Academy of Science, Washington, pp. 133-138.
Zhmurov, V. A. et al. (1991) "Parameters of Destabilized Cellular Membrane and Urolithiasis" Urol. Nefrol-Moscow May-Jun. (3):12-15.
Azoury, R. et al. (1990) "Hydration Feature of Urinary Compounds" Urological Research 18:7-11.
Schrier, E. E. et al. (1979) "Macromolecular Inhibitors of Calcium Oxalate Crystal Growth and Aggregation in Urine" Oxalate in Human Biochemistry and Clinical Pathology, pp. 22-27.
Bose, P. K., S. N. Bhatacharyya (1936) "On the Constitution of an Acid Isolated from Pineapple" Science and Culture 2:162.
Thomas, William Thomas, Jr. MD (1988) "Kidney Stones, Urine, and Cement" American Journal Kidney Disease 37(11):861-862.
Coe, F. L. et al. (1991) "Inhibitors Within the Nephron" American Journal of Kidney Diseases 17(4):407-413.
Lewis, B. D. (1990) "Determination of Citrate in Urine by Simple Direct Photometry-Letters to the Editor" Clinical Chemistry 35(3):578.
Varaprasad D.V.P.R. et al. (1986) "Synthesis of polyfunctional hydroxmic acids for potential use in iron chelation therapy" Chemical Abstracts 105(1):43, abstract No. 458.
Millan, A. et al. (1987) "Determination of Citrate in Urine by Simple Direct Photometry" Clinical Chemistry 33(7):1259-1260.
Batich Christopher D.
Purich Daniel L.
Thomas, Jr. William C.
Rose Shep K.
The University of Florida
LandOfFree
Dicitrate cyclic diester dentifrice does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Dicitrate cyclic diester dentifrice, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dicitrate cyclic diester dentifrice will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-339623