Dichloro-substituted imidazole derivatives as antifungal agents

Details Dichloro-substituted imidazole derivatives as antifungal agents Dichloro-substituted imidazole derivatives as antifungal agents

1992-05-19

1993-01-05

Morris, Patricia L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5483451, A61K 31415, C07D23358

Patent

active

051770997

ABSTRACT:
Dichloro-substituted 1-(5H-dibenzo[a,d]cyclohepten-5-yl)-1H-imidazole comnds of formula (I), in which --X-- is either --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--, and their pharmaceutically acceptable addition salts, preferably the nitric acid ones. Products of formula (I) are prepared from products of formula (VI) where Z represents a leaving group such as halogen, by treatment with an excess of imidazole in dimethylformamide. Products (I) show an antifungal activity comparable -or superior- to antimycotics in the market, such as Clotrimazole and Bifonazole. ##STR1##

REFERENCES:
patent: 3660577 (1972-05-01), Buchel et al.
patent: 3666862 (1972-05-01), Buchel et al.
patent: 3764609 (1973-10-01), Van Der Stelt
patent: 4420474 (1983-12-01), Sykes
PCT Publication No. WO88/03138 of Schering Corporation May 1988.

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