Dicarboxylic acids and derivatives

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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260515P, 2602471T, 260518R, 260518A, 2602472R, 260519, 260520D, 2602472B, 260546, 260558R, 2602475R, 260558A, 260559R, 260268PC, 260556A, 260578, 26029362, 260586R, 260592, 260295F, 260599, 260611A, 26032633, 260618R, 260618D, 2603265C, 260649R, 424308, 2603436, 424309, 424316, 2603461R, 424317, 424319, 2603475, 424324, 2602477Z, 2604105, 260544B, 260448R, 260465R, 260465D, 260465E, 260465F, 260465G, 260465H, 260468J, 260469, 260471R, 260473F, 260476C, 260479R, 2605011, 26050111, 26050115, 26050117, 260515R

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active

039404340

ABSTRACT:
Benzocycloalkenderivatives substituted in 1-position by carboxyl and carboxyalkyl or two carboxyl groups, and further substituted in the benzene ring by cycloalkyl and optionally other substituents, their esters, amides and pharmaceutically acceptable salts have antiinflammatory and analgesic activity and can be used for the treatment of inflammatory conditions and pain in mammals; a representative embodiment is 1-methoxycarbonyl-5-cyclohexyl-6-chloro-1-indanecarboxylic acid.

REFERENCES:
patent: 2507473 (1950-05-01), Koelsch
patent: 3507881 (1970-04-01), Sandberg
patent: 3565904 (1971-02-01), Juby et al.
patent: 3565943 (1971-02-01), Juby et al.
patent: 3696111 (1972-10-01), Juby et al.
patent: 3763229 (1973-10-01), Noguchi et al.
patent: 3772343 (1973-11-01), Noguchi et al.
Minssen et al., Bull. Soc. Chim. France, No. 5 pp. 2111-2117 (1968).
Chemical Abstracts, Vol. 78, 119272r, (1973).
Juby et al., J. Med. Chem., Vol. 15, No. 12, pp. 1297-1310 (1972).

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