Dibenzylamine compounds and pharmaceutical use thereof

Details Dibenzylamine compounds and pharmaceutical use thereof Dibenzylamine compounds and pharmaceutical use thereof

2007-11-13

2010-10-05

Chung, Susannah (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S250000

Reexamination Certificate

active

07807701

ABSTRACT:
A dibenzylamine compound represented by the formula (1)wherein R1and R2are each a C1-6allyl group optionally substituted by halogen atoms and the like; R3, R4and R5are each a hydrogen atom, a halogen atom and the like, or R3and R4may form, together with carbon atoms bonded thereto, a homocyclic or heterocyclic ring optionally having substituent(s); A is —N(R7)(R8) and the like; ring B is an aryl group or a heterocyclic residue; R6is a hydrogen atom, a halogen atom, a nitro group, a C1-6allyl group and the like; n is an integer of 1 to 3, a prodrug thereof and a pharmaceutically acceptable salt thereof show selective and potent CETP inhibitory activity, and therefore, they can be provided as therapeutic or prophylactic agents for hyperlipidemia or arteriosclerosis and the like.

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