Dibenzoxazepine compounds useful in the treatment of cerebral va

Details Dibenzoxazepine compounds useful in the treatment of cerebral va Dibenzoxazepine compounds useful in the treatment of cerebral va

1990-07-24

1991-05-21

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540547, C07D27306, A61K 3155

Patent

active

050175700

ABSTRACT:
Disclosed is a therapeutic agent for the treatment of peripheral circulatory disorders that contains as the effective ingredient a dibenzoxazepin derivative of the following formula or a pharmaceutically acceptable salt thereof: ##STR1## where R.sub.1 is a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group; R.sub.2 is a hydrogen atom or a lower alkyl group; and A signifies the group ##STR2## (where R.sub.3 is a hydrogen atom, a lower alkyl group, an optionally substituted phenyl group or a styryl group). Also, disclosed is a method for treatment of peripheral circulatory disorders by administering the compound of the formula (I) or a pharmaceutically acceptable salt thereof to a patient suffering from such disorders.

REFERENCES:
patent: 4435391 (1984-03-01), Sasahara et al.
Wada et al., Atherosclerosis, vol. 40, No. 3-4, 1981, pp. 263-271.
Patent Abstracts of Japan, vol. 7, No. 259 (C-195), (1404), Nov. 18, 1983.
Patent Abstracts of Japan, vol. 6, No. 54 (C-97) (932), Apr. 9, 1982.
Patent Abstracts of Japan, vol. 6, No. 57 (C-98) (935), Apr. 4, 1982.
European Journal of Pharmacology, vol. 178, No. 2, 1990, pp. 255-258, Amsterdam, NL, M. Sugawa et al., "A Novel Dibenzoxazepine Derivative (BY-1949) Increases Regional Cerebral Blood Flow".

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