Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1998-11-17
2000-04-18
Davis, Zinna Northington
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
549382, 546 33, C07D31178, C07D22118
Patent
active
060517190
ABSTRACT:
Dibenzorhodamine compounds having the structure ##STR1## are disclosed, including nitogen- and aryl-substituted forms thereof. In addition, intermediates useful for synthesizing such compounds are disclosed, such intermediates having the structure ##STR2## In Formula I, R.sub.1 is H or ##STR3## wherein Y is H, lower alkyl, lower alkene, lower alkyne, aromatic, phenyl, polycyclic aromatic, heterocycle, water-solubilizing group, or linking group, including substituted forms thereof. When R.sub.1 is H, the C-12-bonded nitrogen and the C-12 and C-13 carbons form a first ring structure having from 4 to 7 members, and/or the C-12-bonded nitrogen and the C-11 and C-12 carbons form a second ring structure having from 5 to 7 members. The compounds of Formula I further include aryl- and nitrogen-substituted forms thereof. The invention further includes energy transfer dyes comprising the dibenzorhodamine compounds, nucleosides labeled with the dibenzorhodamine compounds, and nucleic acid analysis methods employing the dibenzorhodamine compounds.
REFERENCES:
Tsunoda et al., "Naphthazolylphenyl azides," Chemical Abstracts 83(14):75 (Oct. 6, 1975).
Onda et al., "Heterocycles. IV. Photolyses of the 4-Arylacetylated 1,2-Dihydroisoquinoline, Isocarbostyril and Its Enol Acetates," Chemical and Pharmaceutical Bulletin 25(11):2935-2941 (Mar. 12, 1977).
Takai, Hideyuki, "Electrophotographic photoconductors," Chemical Abstracts 114(22):743 (Jun. 3, 1991).
Sotomayer et al., "Bischler-Napieralski Cyclization-N/C-Alkylation Sequences for the Construction of Isoquinoline Alkaloids. Synthesis of Protoberberines and Benzo[c]phenanthridines via C-2'-Functionalized 3-Arylisoquinolines.sup.1 " Journal of Organic Chemistry 61(12):4062-4072 (1996).
Benson Scott Conrad
Lam Joe Y. L.
Menchen Steven Michael
Radel Peggy Ann
Upadhya Krishna Gajanan
Andrus Alex
Davis Zinna Northington
Grossman Paul D.
The Perkin-Elmer Corporation
LandOfFree
Dibenzorhodamine dyes does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Dibenzorhodamine dyes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dibenzorhodamine dyes will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2337226