Dibenzoheterocyclic hydroxamic acids and hydroxy ureas as inhibi

Details Dibenzoheterocyclic hydroxamic acids and hydroxy ureas as inhibi Dibenzoheterocyclic hydroxamic acids and hydroxy ureas as inhibi

1990-03-14

1991-07-30

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514211, 514431, 514434, 514436, 540551, 544350, 544 38, 544 39, 549 10, 549 11, 549 12, 549 16, 549 17, A61K 3154, A61K 3155, C07D27918, C07D28112

Patent

active

050360671

ABSTRACT:
Compounds having the formula I: ##STR1## are inhibitors of the 5-lipoxygenase enzyme. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea, and migraine.

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P. K. Kadaba, The Synthesis of Some Phenothiazinyl Ketones and Their Derivatives, J. Het. Chem. 3, 345 (1966).
C. M. Suter, et al., The Directive Influences of Oxygen and Sulfur, J.A.C.S. 58, 717 (1936).

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