Dibenzocycloheptene compound

Details Dibenzocycloheptene compound Dibenzocycloheptene compound

2007-12-18

2007-12-18

Saeed, Kamal A. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

C562S400000, C562S405000

Reexamination Certificate

active

10481752

ABSTRACT:
The present invention discloses a dibenzocycloheptene compound represented by the formula (I):wherein R1: hydrogen atom, halogen atom, etc., R2: hydrogen atom, halogen atom, etc., A: 5-membered or 6-membered heteroaromatic ring group containing 1 to 3 hetero atom(s) selected from the group consisting of nitrogen atom, oxygen atom and sulfur atom, and the heteroaromatic ring group, etc. may have halogen atom, nitrogen atom, etc. as substituent(s), B: formula; —CH═CH—, formula; —CH2O—, etc., Y: C1-C10alkylene group which may have halogen atom, etc. as substituent(s), etc., Z: carboxyl group which may be protected, etc., m: an integer of 1 to 4, n: an integer of 1 to 3,represents a single bond or a double bond,or a pharmaceutically acceptable salt thereof and a medical composition containing the same as an effective ingredient which has leukotriene C4antagonistic action and leukotriene E4antagonistic action in addition to potent leukotriene D4antagonistic action, and useful as antiasthmatic agent, antiallergic agent and anti-inflammatory agent.

REFERENCES:
patent: 4235820 (1980-11-01), Evans
patent: 6602901 (2003-08-01), Jeppesen et al.
patent: 6723731 (2004-04-01), Jeppesen et al.
patent: 468785 (1992-01-01), None
patent: 685478 (1995-12-01), None
patent: WO 01/47889 (2001-07-01), None

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