Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Patent
1980-09-24
1983-10-18
Killos, Paul J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
560 56, 560 52, 560 50, 562461, 562466, 562460, 562488, 562459, 424308, 2604109R, 260465H, 568308, 568325, 568807, C07C 6976
Patent
active
044107161
ABSTRACT:
Novel compounds, dibenzo[a,d]cycloheptene derivatives, of the general formula ##STR1## wherein R.sub.1 represents a hydrogen atom, a halogen atom or a lower alkyl group, R.sub.2 and R.sub.3 each represent a hydrogen atom or a lower alkyl group, and Z represents a group of the formula ##STR2## These novel compounds are useful as non-steroidal anti-inflammatory agents free from gastrointestinal lesions. The compounds of formula (I) can be prepared, for example, by cyclizing a compound of the general formula ##STR3## wherein R.sub.1 and R.sub.2 are as defined above, X represents a hydroxyl group or a halogen atom, one Y represents a group of the formula --CH.sub.2 COX and the other Y represents a hydrogen atom; optionally hydrolyzing the cyclized product; and optionally esterifying the product, and/or etherifying its enol group.
REFERENCES:
patent: 3933905 (1976-01-01), Brunet et al.
patent: 3966820 (1976-06-01), Nelson et al.
patent: 3975437 (1976-08-01), Brunet et al.
Goto Takao
Hayasaka Tetsutaro
Narita Sen-ichi
Okutani Kazuyoshi
Saito Kuniro
Killos Paul J.
Toa Eiyo Kagaku Kogyo Co. Ltd.
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