Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1984-06-26
1986-06-24
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514305, 514382, 514450, 544366, 544378, 546134, 548252, 549354, A61K 31495, C07D40504
Patent
active
045968047
ABSTRACT:
A dibenz[b,e]oxepin compound having an antiallergic activity is represented by the following general formula: ##STR1## wherein R.sub.1 represents a cyano group, a 5-tetrazolyl group, a carbamoyl group or --CO.sub.2 R.sub.3 wherein R.sub.3 represents a hydrogen atom, an alkyl group having 1 to 5 carbon atoms or a 1-(ethoxycarbonyloxy)ethyl group, and R.sub.2 represents a 4-alkylpiperazino group wherein the alkyl group has 1 to 5 carbon atoms, a 3-quinuclidinylamino group or --X--(CH.sub.2).sub.n --NR.sub.4 R.sub.5 wherein X represents --NH--, --S -- or --O--, R.sub.4 and R.sub.5 are same or different and each represents an alkyl group having 1 to 5 carbon atoms and n represents 2 or 3; and the pharmaceutically acceptable acid addition salts or metal salts thereof.
REFERENCES:
patent: 3509176 (1970-04-01), Winter et al.
patent: 4011222 (1977-03-01), Gerecke et al.
patent: 4032525 (1977-06-01), Gerecke et al.
patent: 4144337 (1979-03-01), Bastian
Ohmori Kenji
Oiji Yoshimasa
Shuto Katsuichi
Takizawa Hiroshi
Hollrah Glennon H.
Kyowa Hakko Kogyo Co. Ltd.
Turnipseed James H.
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