Diazonium salt for bilirubin assay

Details Diazonium salt for bilirubin assay Diazonium salt for bilirubin assay

1982-02-01

1984-08-28

Turk, Arnold

Chemistry: analytical and immunological testing

Heterocyclic carbon compound

Hetero-n

260141, 422 56, 436903, C07C11300, G01N 3372

Patent

active

044684673

ABSTRACT:
Diazonium salts which are useful in an assay for bilirubin are disclosed. The novel salts have the structural formula: ##STR1## wherein X.sup.- is a stabilizing anion, Y is CO-- or SO.sub.2 --; and R.sup.1 and R.sup.2 are independently selected from hydrogen, alkyl, aryl, carboxyalkyl and hydroxyalkyl providing R.sup.1 and R.sup.2 are not both hydrogen; R.sup.3 and R.sup.4 are independently selected from groups such that the sum of the Hammett sigma values for R.sup.3 and R.sup.4 does not exceed +0.4 or R.sup.3 and R.sup.4 represent the carbon atoms necessary to complete a fused carbocyclic ring structure. Reagent compositions, analytical elements and methods which use the described diazonium salt are also disclosed.

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Chin-Chung Chen et al., "Sulfanilamide for the Determination of Total Bilirubin", Clin. Chem., vol. 26, No. 7, p. 990, 1980.

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