Diaziridinylpolyamine anti-cancer agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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548962, A61K 31395, C07D40312

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active

056123299

ABSTRACT:
Diaziridinylpolyamines useful as anti-cancer agents; compositions containing the same, and methods of using the same for the treatment of cancer are described.

REFERENCES:
Hartley et al, "An Agarose Gel Method for the Determination of DNA Interstand Crosslinking Applicable to the Measurement of the Rate of Total and Second-Arm Crosslink Reactions", Analytical Biochemistry, 193:131-134 (1991).
Byers et al, "Properties and Physiological Function of the Polyamine Transport System", Am. J. Physiol., 257(Cell Physiol. 26):C545-C553 (1989).
Monks et al, "Feasibility of a High-Flux Anticancer Drug Screen Using a Diverse Panel of Cultured Human Tumor Cell Lines", J. Natl. Cancer Inst., 83(11):757-766 (1991).
Porter et al, "Aliphatic Chain Length Specificity of the Polyamine Transport System in Ascites L1210 Leukemia Cells", Cancer Res., 44:126-128 (1984).
Porter et al, "Biological Properties of N.sup.4 -Spermidine Derivatives and Their Potential in Anticancer Chemotherapy", Cancer Res., 42:4072-4078 (1982).
Yuan et al, "Cytotoxicity of Aziridinyl Analogues of Polyamines Against L1210 and HL60 Cells", Abstract 2264, American Association of Cancer Researchers, Orlando, Florida (May 20, 1993) p. 380.
Lee et al, "DNA Interactions with Aziridinyl Analogues of Polyamides", Abstract (94.65), Student Research Form, p. 38, (Aug. 10, 1994) University of Maryland Medical Center, 17th Annual Medical Science Research Day-1994.
Li et al, "In Vivo Evaluation of Bisaziridinylspermine in a Murine L1210 Model", Abstract (2313), Experimental Therapeutics, Proceedings of the American Association for Cancer Research, 36:388 (1995) p. 388.
Rosen et al, "Cytotoxicity and Cellular Pharmacology of Bisaziridinylspermine", Abstract (2314) Experimental Therapeutics, Proceedings of the American Association for Cancer Research, 36:388 (1995) p. 388.
Ballesteros et al, "L1210 Cell Spermidine Transport: Structure-Function Relationships Among Polyamine Analogous", Abstract (3017), Molecular Biology/Biochemistry, Proceedings of the American Association for Cancer Research, 36:507 (1995).
Simon et al, "Cellular Pharmacology of a Polyamine analogue", Abstract (94.09), 17th Annual Medical Science Research Day-1994, p. 8 (Aug. 10, 1995), and Poster (Sep. 14, 1994).
Cohen et al, "Targeting of Cytotoxic Agents by Polyamines: Synthesis of a Chlorambucil-Spermidine Conjugate", J. Chem. Soc. Chem. Commun., pp. 298-300 (1992).
Holley et al, "Targeting of Tumor Cells and DNA by a Chlorambucil-Spermidine Conjugate", Cancer Res., 52:4190-4195 (1992).
Nagarajan et al, "Chemistry of Naturally Occurring Polyamines. 10..sup.1 Nonmetabolizable Derivatives of Spermine and Spermidine", J. Org. Chem., 51:4856-4861 (1986).
Darcel et al, "The Antitumoral Action of Polyamine Linked Cyclophosphazenes on Human Malignant Glioma Heterografts in nu
u Mice", Anticancer Research, 10:1563-1570 (1990).
Stark et al, "Synthesis and Evaluation of Novel Spermidine Derivatives as Targeted Cancer Chemotherapeutic Agents", J. Med. Chem., 35:4264-4269 (1992).
Porter et al, "Relative Abilities of Bis(ethyl) Derivatives of Putrescine, Spermidine, and Spermine to Regulate Polyamine Biosynthesis and Inhibit L1210 Leukemia Cell Growth", Cancer Res., 47:2821-2825 (1987).
Heston et al, "Cytotoxic Activity of Aziridinyl Putrescine Enhanced by Polyamine Depletion with Alpha-Difluoromethylornithine", Biochem. Pharm., 34(13):2409-2410 (1985).
Callery et al, "Synthesis and Antitumor Evaluation of a Highly Potent Cytotoxic DNA Cross-linking Polyamide Analogue, 1,12-Diaziridinyl-4,9-Diazadodecan", Abstract (028), American Chemical Society, Division of Medicinal Chemistry, 209th ACS National Meeting, Anaheim, California (Apr. 2-6, 1995) (no pg. #).
Tabor et al, "Polyamines", Ann. Rev. Biochem., 53:749-790 (1984).
Pegg, "Polyamine Metabolism and Its Importance in Neoplastic Growth and as a Target for Chemotherapy", Cancer Research, 48:759-774 (1988).
Sepp anen, "Some Properties of the Polyamine Deprivation-Inducible Uptake System for Methylglyoxal Bis(guanylhydrazone) in Tumor Cells", Acta Chemica Scandinavica B, 35:731-736 (1981).
Hemminki et al, "Correlations of Alkylating Activity and Mutagenicity in Bacteria of Cytostatic Drugs", Acta Pharmacol et Toxicol, 53:421-428 (1983).
Musser et al, "Alkylation of DNA with Aziridine Produced During the Hydrolysis of N,N',N"-Triethylenethiophosphoramide", Chem. Res. Toxicol., 5(1):95-99 (1992).
Metzler, "DNA Adducts of Medicinal Drugs: Some Selected Examples", J. Cancer Res. Clin. Oncol., 112:210-215 (1986).
Farmer, "Metabolism and Reactions of Alkylating Agents", Pharmac. Ther., 35:301-358 (1987).
Heston et al, "Cytotoxic and Non-cytotoxic N-alkyl Derivatives of Putrescine: Effect on Polyamine Uptake and Growth of Prostatic Cancer Cells In Vitro", Biochemical Pharmacology, 36(11):1849-1852 (1987).
Piper et al, "S-2-(.omega.-Aminoalkylamino)ethyl Dihydrogen Phosphorothioates and Related Compounds as Potential Antiradiation Agents", Potential Antiradiation Agents, 12:236-243 (Mar. 1969).
O'Sullivan et al, "Molecular Features Necessary for the Uptake of Diamines and Related Compounds by the Polyamide Receptor of Rat Lung Slices", Biochemical Pharmacology, 41(12):1839-1848 (1991).
Dueymes et al, "Modulation of Polyclonal Activation of Lymphocytes by Cytophosphazenic Compounds Bearing Ethylene-Imino Groups and Vectorized by Polyamines", Int. J. Immunopharmac., 12(5):555-560 (1990).
Yuan et al, "Cytotoxic Activity of N.sup.1 -and N.sup.8 -Aziridinyl Analogs of Spermidine", Biochemical Pharmacology, 47(9):1587-1592 (1994).
Hyy onen et al, "Characterization of a COS Cell Line Deficient in Polyamine Transport", Biochemica et Biophysica Acta, 1221:279-285 (1994).
Lakanen et al, ".alpha.-Methyl Polyamines: Metabolically Stable Spermidine and Spermine Mimics Capable of Supporting Growth in Cells Depleted of Polyamines", J. Med. Chem., 35:724-734 (1992).
Boyd et al, "Some Practical Considerations and Applications of the National Cancer Institute In Vitro Anticancer Drug Discovery Screen", Drug Development Research, 34:91-109 (1995).
Yuan et al, "Potent Cytotoxic Aziridinyl Analogues of Polyamides", Abstract (2264), Experimental Therapeutics, Proceedings of the American Association for Cancer Research, 34:380 (1993).
Yuan et al, "Cytotoxic Monoaziridinylspermidines", Abstract (129), Medi, American Chemical Society, 204th ACS National Meeting, Washington, D.C. (Aug. 23-28, 1992) (no page No.).

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