Diaziridinyl-aryl and bis-[di(chloroethyl)amino]-aryl oligonucle

Details Diaziridinyl-aryl and bis-[di(chloroethyl)amino]-aryl oligonucle Diaziridinyl-aryl and bis-[di(chloroethyl)amino]-aryl oligonucle

1998-08-26

2000-06-06

Riley, Jezia

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 514 1, 514 44, 536 221, 536 253, 536 2532, 536 266, C07H 2102, C07H 2100, C07H 1900, C12Q 168, A01N 4304

Patent

active

060720468

ABSTRACT:
Diaziridinyl-aryl and bis-[di(chloroethyl)amino]-aryl oligonucleotide conjugates have a sequence that is complementary in the triplex forming sense to a target sequence in duplex nucleic acid. The diaziridinyl-aryl and bis-[di(chloroethyl)amino]-aryl oligonucleotide conjugates effectively cross-link with both strands of the targeted duplex nucleic acid.

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