Diazepinoindoles as phosphodiesterase IV inhibitors

Details Diazepinoindoles as phosphodiesterase IV inhibitors Diazepinoindoles as phosphodiesterase IV inhibitors

1995-02-22

1998-12-22

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D24324

Patent

active

058521909

ABSTRACT:
The invention relates to diazepinoindoles of formula: ##STR1## in which R is hydrogen, lower alkyl or lower alkoxy; A is aryl or nitrogen-containing heteroaryl, each of which is optionally substituted by from one to three groups of halogen, lower alkyl, haloalkyl, lower alkoxy and acetamido, or their racemic forms, isomers or pharmaceutically acceptable salts, wherein for the racemic forms of the (S) configuration, A is not phenyl, haloalkyl, or 2-indolyl when R is hydrogen, and for the racemic forms of the (R) configuration, A is not 2-indolyl when R is hydrogen. Also, the invention relates to a method for inhibiting cyclic nucleotide phosphodiesterase activity by administering these compounds to a subject in an amount which is therapeutically effective to inhibit cyclic nucleotide phosphodiesterase activity.

REFERENCES:
patent: 4929614 (1990-05-01), Calvet et al.
patent: 4981847 (1991-01-01), Sato et al.
patent: 5082937 (1992-01-01), Calvet et al.
patent: 5155101 (1992-10-01), Sato et al.
patent: 5248679 (1993-09-01), Sato et al.
Calvet et al, Chemical Abstracts, vol. 116, entry 6583 (1991).

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