Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...
Reexamination Certificate
2005-12-21
2008-12-23
Hartley, Michael G (Department: 1618)
Organic compounds -- part of the class 532-570 series
Organic compounds
Unsubstituted hydrocarbyl chain between the ring and the -c-...
C540S467000, C540S468000, C540S469000
Reexamination Certificate
active
07468434
ABSTRACT:
This invention provides a method for treating an eye disease in a patient comprising: providing a photosensitive prodrug that releases upon exposure to light an active ingredient to treat the eye disease; administering the prodrug in a pharmaceutically accepted vehicle to the subject, and exposing the eye of the subject to an external light source to cause the prodrug to release the active ingredient. This invention also provides a composition for the treatment of glaucoma, comprising a compound containing a lithium ion-chelated in a crown ether- or aza-crown ether-containing chromene or diazene derivative and a pharmaceutically acceptable carrier.
REFERENCES:
Huang et al. “Support of Retinal Ganglion Cell Survival and Axon Regeneration by Lithium through a Bcl-2 Dependent Mechansim”, Investigative Ophthalmology & Visual Science, 44(1), p. 347-354. Jan. 2003.
Birch, N.J., “Biomedical Uses of Lithium,” Uses of Inorganic Chemistry in Medicine, ed. Farrell, N.P., 1999, 11-25.
Birch, N.J., “Inorganic Pharmacology of Lithium,” Chem. Rev., 1999, 1659-2682, vol. 99.
Blank, M. et al., “Photoregulated Ion Binding,” Science, 1981, 70-72, vol. 214.
Cheung, Z.H. et al., “Enhanced Survival and Regeneration of Axotomized Retinal Ganglion Cells by . . . ,” Journal of Neurotrauma, 2002, 369-378, vol. 19, No. 3.
Cho, K.S. et al., “Ciliary Neurotrophic Factor Promotes the Regrowth Capacity but not the Survival of Intraorbitally . . . ,” Neuroscience, 1999, 623-628, vol. 94, No. 2.
Cho, K.S. et al., “Differential Effects of Intravitreal Optic Nerve and Sciatic Nerve Grafts on the Survival . . . ,” Journal of Neurocytology, 2001, 983-991, vol. 30.
Garcia-Valenzuela, E. et al., “Programmed Cell Death of Retinal Ganglion Cells Durig Experimental Glaucoma,” Exp. Eye Res., 1995, 33-44, vol. 61.
Ikeda, T. et al., “Optical Switching and Image Storage by Means of Photochromic Liquid Crystals,” Mol. Cryst. and Liq. Cryst., 2000, 1-13, vol. 347.
Ji, J-Z. et al., “CNTF Promotes Survival of Retinal Ganglion Cells after Induction of Ocular Hypertension in Rats . . . ,” Euro. J. Neurosci., 2004, 265-272, vol. 19.
Laquis, S. et al., “The Patterns of Retinal Ganglion Cell Death in Hypertensive Eyes,” Brain Research, 1998, 100-104, vol. 784.
Leske, M.C., “The Epidemiology of Open-Angle Glaucoma: A Review,” American Journal of Epidemiology, 1983, 166-191, vol. 118, No. 2.
Levy, D., “Recent Applications of Photochromic Sol-Gel Materials,” Mol. Cryst. Liq. Cryst., 1997, 31-39, vol. 297.
Lorincz, E. et al., “Polarization Holographic Data Storage Using Azobenzene Polyester as Storage Material,” 2003, 34-44, vol. 4991.
Lu, Q. et al., “c-Jun Expression in Surviving and Regenerating Retinal Ganglion Cells . . . ,” Investigative Opththalmology & Visual Science, 2003, 5342-5348, vol. 44, No. 12.
Matsui, F. et al., “Application of Photochromic 5-Dimethylaminoindolylfulgide to Photon-Mode Erasable Optical Memory Media . . . ,” Chemistry Letters, 1994, 1869-1872.
McKinnon, S.J., et al. “Baculoviral IAP Repeat-Containing-4 Protects Optic Nerve Axons in a Rat Glaucoma Model,” Molecular Therapy, 2002, 780-787, vol. 5, No. 6.
Mittag, T.W. et al., “Retinal Damage after 3 to 4 Months to Elevated Intraocular Pressure in a Rat . . . ,” Invest. Ophthamol. & Vis. Sci., 2000, 3451-3459, vol. 41, No. 11.
Morrison, J.C. et al., “A Rat Model of Chronic Pressure-Induced Optic Nerve Damage,” Exp. Eye. Res., 1997, 85-96, vol. 64.
Natansohn, A. and Rochon, P., “Photoinduced Motions in Azobenzene-Based Amorphous Polymers . . . ,” Adv. Mater., 1999, 1387-1391, vol. 11, No. 16.
Nunzi, J.M. et al., “Limits of Use of Polymer Thin-Films for Spatial Light Modulation,” SPIE, 138-144, vol. 2969.
Osborne, N.N. et al., “Ganglion Cell Death in Glaucoma: What Do We Really Know?” Br. J. Ophthalmol., 1999, 980-986, vol. 83.
Quigley, H.A. and Green, W.R., “The Histology of Human Glaucoma Cupping and Optic Nerve Damage . . . ,” Ophthalmology, 1978, 1803,-1830, vol. 86.
Rompotis, S. et al., “Determination of Valproic Acid in Human Plasma by HPLC . . . ,” Journal of Liquid Chromatography & Related Technologies, 2002, 2833-2847, vol. 25, No. 18.
Sawada, A. and Neufeld, A.H., “Confirmation of the Rat Model of Chronic, Moderately Elevated Intraocular Pressure,” Exp Eye Res., 1999, 525-31, vol. 69.
Shanzer, A. et al., “Lipophilic Lithium Ion Carriers,” J. Am. Chem. Soc., 1983, 3815-3818, vol. 105.
Shinbo, K. et al., “In Situ Investigations on the Preparations of Layer-by-Layer Films Containing . . . ,” Materials Science and Engineering C, 2002, 319-325, vol. 22.
Shinkai, S. et al., “Photoresponsive Crown Ethers. 1. Cis-Trans Isomerism of Azobenzene as a Tool to Enforce . . . ,” J. Am. Chem. Soc., 1980, 5860-5865, vol. 102.
Shinkai, S. et al. “Photoresponsive Crown Ethers. 2. Photocontrol of Ion Extraction and Ion Transport by a Bis(Crown Ether) . . . ,” J. Am. Chem. Soc., 1981, 111-115, vol. 103.
Siu, A.W. et al., “Total Retinal Nitric Oxide Production is Increased in Intraocular Pressure-Elevated Rats,” Exp. Eye Res., 2002, 401-406, vol. 75.
Stauffer, M.T. et al., “Optical Control Over Pb2+ Binding to a Crown Ether-Containing Chromene,” Chem. Commun., 1997, 287-288.
Ueda, J. et al., “Experimental Glaucoma Model in the Rat Induced by Laser Trabecular Photocoagulation . . . ,” Jpn. J. Ophthalmol., 1998, 337-344, vol. 42.
Woldemussie, E. et al., “Neuroprotection of Retinal Ganglion Cells by Brimonidine in Rats with Laser-Induced . . . ,” Invest. Ophthalmol. & Vis. Sci., 2001, vol. 42, No. 12.
Woldemussie, E. et al., “Neuroprotective Effect of Memantine in Different Retinal Injury Models in Rats,” Journal of Glaucoma, 2002, 474-480, vol. 11.
Yoon, H.C. et al., “Fabrication of Azobenzene-Terminated Dendrimers and Application to Photoswitching Devices,” Synthetic Metals, 2003, 1427-1428, vol. 137.
You, S-W. et al., “Axonal Regenerationof Retinal Ganglion Cells After Optic Nerve Pre-Lesions . . . ,” Visual Neuroscience, 2002, 661-668, vol. 19.
Zhang, X.H. et al., “A New Family of Red Dopants Based on Chromene-Containing Compounds for Organic . . . ,” Chem. Mater., 2001, 1565-1569, vol. 13.
Zhang, Z. et al., “A Water-Soluble Azobenezene Cross-Linker for Photocontrol of Peptide Conformation,” Bioconjugate Chem., 2003, 824-829, vol. 14.
Che Chi-Ming
Sham Iona Hiu Tung
So Kwok-Fai
Vanhoutte Paul Michel Georges
Cooper & Dunham LLP
Hartley Michael G
Katz Robert D.
The University of Hong Kong
Westerberg Nissa M
LandOfFree
Diazene-bridge crown ether lithium compounds and methods for... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Diazene-bridge crown ether lithium compounds and methods for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diazene-bridge crown ether lithium compounds and methods for... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4050884