Diazatetracyclododecanes

Details Diazatetracyclododecanes Diazatetracyclododecanes

1976-04-14

1977-07-05

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260287B, 260283S, 260283CN, 424258, C07D47108, A61K 31435

Patent

active

040339688

ABSTRACT:
A new heterocycle, 5,11-diazatetracyclo[6.2.2.0.sup.2,7.0.sup.4.9 ]dodecane, is prepared by heating an endo-diazatricyclo[6.2.2.0.sup.2,7 ]dodec-11-ene substituted in the 7 and 11 positions with electron withdrawing groups. 2,9-Bis-phenylacetyl derivatives of the new heterocycle and closely related derivatives are potent analgesic agents.

REFERENCES:
patent: 3932422 (1976-01-01), Michne
Liberatore et al., Tetrahedron Letters, pp. 2381-2384 (1971).
Hirao et al., J. Chem. Soc. Chem. Comm. pp. 691-692 (1974).

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