Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1979-03-05
1981-11-03
Daus, Donald G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
544279, 544281, 424251, 424253, C07D48712, C07D48714
Patent
active
042987342
ABSTRACT:
Imidazopyrimidinones and other diazaheterocyclopyrimidinones having an additional fused imidazole or triazole ring have utility as bronchodilators, mediator release inhibitors, phosphodiesterase inhibitors, and peripheral vasodilators. They are orally active and useful in the prophylaxis and treatment of asthma. A preferred compound is 4-[(4-chlorophenyl)methyl]-6,7-dihydro-3H-imidazo[1,2-a]-purin-9(4H)-one.
REFERENCES:
patent: 3859289 (1975-01-01), Hardtmann
patent: 3894022 (1975-07-01), Hardtmann
patent: 3969506 (1976-07-01), Hardtmann
patent: 3982000 (1976-09-01), Hardtmann
Hardtman et al., J. Med. Chem. 18, pp. 447-453 (1975).
Seidehamel Abst. of Papers 175th Mat. ACS Mtg. 3/13/78, Abstr. No. 8, Med. Chem. Section.
Seidehamel et al., Amer. Chem. Soc. Symposium Series 118, 1980, pp. 293-297.
Temple J. Med. Chem., vol. 23, pp. 1188-1198 (1980).
Kamiya et al., Japanese Pat. 74-28,760, cited in C.A., vol. 182, (1975), Abst. No. 140,190e.
Carnahan Robert E.
Daus Donald G.
Mead Johnson & Company
Springer D. B.
Uloth Robert H.
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