Diazacycloalkyl-1,2,4-triazolo[2,3-c][1,3]benzodiazepines useful

Details Diazacycloalkyl-1,2,4-triazolo[2,3-c][1,3]benzodiazepines useful Diazacycloalkyl-1,2,4-triazolo[2,3-c][1,3]benzodiazepines useful

1984-08-22

1986-06-17

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602455, 514220, 514254, 514383, 514384, 544366, 548262, C07D48716, A61K 31495

Patent

active

045955352

ABSTRACT:
Described are 5-diazacycloalkyltriazolo[2,3-c][1,3]benzodiazepines, for example compounds of the formula ##STR1## wherein R.sub.1 represents hydrogen, halogen, trifluoromethyl, lower alkylthio, lower alkoxy or lower alkyl; R.sub.2 represents hydrogen, lower alkyl or hydroxy-C.sub.2 -C.sub.7 alkyl wherein the hydroxy group is separated from the nitrogen atom by at least 2 carbon atoms; R.sub.3 represents hydrogen, lower alkyl, lower alkoxy, lower alkylthio, halogen or trifluoromethyl; and C.sub.n H.sub.2n represents ethylene. The synthesis, pharmaceutical compositions and methods of use as neuroleptic and/or antihistaminic agents are given.

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