Diazaborines and drug compositions

Details Diazaborines and drug compositions Diazaborines and drug compositions

1978-07-27

1980-04-22

Sneed, Helen M. S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

2605023, A61K 3169, A61L 1300, A61L 2300, C07F 502

Patent

active

041995732

ABSTRACT:
Derivative of 1-hydroxy-benzo-2,3,1-diazaborines which are substituted in the 2-position by a sulfo group linked to a defined aliphatic radical like alkyl or alkenyl and which may be substituted on the benzene ring by one or more lower alkyl radicals and/or halogen atoms and salts of such compounds. The pharmaceutical compositions containing these diazaborines are highly effective against gram-negative bacteria. The new compounds are prepared by reacting o-formyl phenyl boric acid, which may be substituted, with the respective aliphatic sulfonic acid hydrazide or by reacting the respective (substituted) benzaldehyde sulfonylhydrazone with a boron trihalogenide.

REFERENCES:
patent: 3714206 (1973-01-01), Huemer et al.
patent: 4112077 (1978-09-01), van Wersch et al.

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