Diazabicyclooctanes and diazabicycloheptanes

Details Diazabicyclooctanes and diazabicycloheptanes Diazabicyclooctanes and diazabicycloheptanes

1975-08-21

1976-03-30

Rollins, Alton D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424250, C07D45102, C07D48708

Patent

active

039474453

ABSTRACT:
Twelve analogs of diethylcarbamazine as prepared by acylation of 3- and 8-methyl-3,8-diazabicyclo[3.2.1]octane, 2-methyl-2,5-diazabicyclo[2.2.2]octane, and 2-methyl-2,5-diazabicyclo [2.2.1]heptane with diethylcarbamyl chloride, ethyl chloroformate, ethyl isocyanate, and cyclohexanecarbonyl chloride. These compounds are formally derived from diethylcarbamazine in possessing two- or one-carbon bridges over the piperazine ring. The compounds have utility as antifilarial agents and as bronchodilators.

REFERENCES:
adel Ayad Mikhail Chemical Abstracts Vol. 68, 12953 e, (1968).

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