Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1993-05-12
1995-05-23
Bernhardt, Emily
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514242, 514248, 544182, 544215, 544230, 544235, 548423, 548431, 549239, 549387, 549398, 549401, 549405, 549427, A61K 3153, A61K 3150, C07D40512, C07D47104
Patent
active
054182328
ABSTRACT:
A compound of formula (I) possesses excellent potassium channel opening activity and is effective on various diseases arising from contractions of blood vessels, bronchial smooth muscles, etc., for example, ischemic heart diseases exemplified by angina pectoris, asthma, pollakisuria, sequela of subarachnoid hemorrhage, peripheral arterioinfarct, and so on. The compound has potent and long-lasting antihypertensive activity, with the onset of the action being slow, excellent activity in increasing renal blood flow, and high safety, and is therefore particularly useful as an antihypertensive. ##STR1## The substituents are as defined in the specification.
REFERENCES:
patent: 5013853 (1991-05-01), Gericke et al.
patent: 5112972 (1992-05-01), Gericke et al.
Bergmann et al Journal of Medicinal Chemistry, vol. 33, pp. 2759-2767 (1990).
3-Methyl-2H-1-benzopyran Potassium Channel Activators, Rolf Gericke et al, J. Med. Chem. 1991, 34, 3074-3085.
Kubo Hideo
Mimura Tetsuya
Bernhardt Emily
Daiichi Pharmaceutical Co. Ltd.
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