Diastereoselective synthesis process for the preparation of...

Details Diastereoselective synthesis process for the preparation of... Diastereoselective synthesis process for the preparation of...

2005-04-28

2008-11-25

Dentz, Bernard (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07456287

ABSTRACT:
A diastereoselective synthesis process for the preparation of an enantiomer of 6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone which comprises the conversion of (±)-6-[chloro(4-chlomphenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone into a compound of formula (VIII) wherein aryl is phenyl substituted once or twice with C1-6alkyloxy or naphtalenyl substituted once or twice with C1-6alkyloxy.

REFERENCES:
patent: WO 97/21701 (1997-06-01), None
patent: WO 01/53289 (2001-07-01), None
patent: WO 02/072574 (2002-09-01), None
Angibaud, P.R., et al. “Synthesis Routes Towards the Farnesyl Protein Transferase Inhibitor Zarnestra” European Journal of Organic Chemistry. vol. 3 (23004) pp. 479-486.
International Search Report PCT/EP2005/051934 mailed Dec. 7, 2005.

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