Diastereoselective reduction of alpha-triazolylketones to betatr

Details Diastereoselective reduction of alpha-triazolylketones to betatr Diastereoselective reduction of alpha-triazolylketones to betatr

1985-05-02

1988-05-31

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D24908

Patent

active

047482508

ABSTRACT:
Sterically pure .beta.-triazolyl carbinols of the general structure ##STR1## where R is not hydrogen, in particular the R*, S*-diastereomer, are obtained by diastereoselective reduction of the corresponding .alpha.-triazolylketone with a complex hydride which reduces ketones to alcohols, in the presence of a Lewis acid in a non-polar solvent.

REFERENCES:
patent: 3952002 (1976-04-01), Kramer et al.
patent: 3972892 (1976-03-01), Buchel et al.
patent: 4232033 (1980-11-01), Kramer et al.
patent: 4243405 (1981-01-01), Balasubramanyan et al.
patent: 4380546 (1983-04-01), Sauter et al.
Roher et al, "Tetrabutylammonium horobydride, etc" JOC, 41 (1976) 690.
Hirao et al "Asymmetric reduction, etc" CA 92:128500e (1980).

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