Diastereoselective process for the preparation of intermediates

Details Diastereoselective process for the preparation of intermediates Diastereoselective process for the preparation of intermediates

1989-05-11

1992-10-20

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 9, 560 22, 560 24, 560 27, 560 29, 560 30, 560 31, 560 32, 560 33, C07C33100

Patent

active

051571439

ABSTRACT:
A diastereoselective process for the preparation of compounds of formula ##STR1## (wherein R and R.sub.1 have the meanings reported in the specification and the asterisks show the asymmetric carbon atoms) starting from the corresponding N-protected 2-amino-3-aryl-propan-1-ol is described.
The compounds of formula I are intermediates useful for the synthesis of pharmacologically active peptides.

REFERENCES:
patent: 4281180 (1981-07-01), Umezawa
patent: 4352752 (1982-10-01), Ojima

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