Diastereomers of 10-alkyl-10-deazaminopterins and process for pr

Details Diastereomers of 10-alkyl-10-deazaminopterins and process for pr Diastereomers of 10-alkyl-10-deazaminopterins and process for pr

1985-12-30

1988-05-24

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514258, 544260, A61K 31505, C07D47508

Patent

active

047466596

ABSTRACT:
Diastereomers of 10-alkyl-10-deazaminopterins are provided, as well as a synthesis for their preparation as the individual d,L. and l,L.-diastereomers, the d,L-10-ethyl diastereomer being three times as potent against L1210 cells as the l,L-10-ethyl diastereomer, and the l,L-10-ethyl diastereomer being approximately one-half as toxic as the d,L-10-ethyl diastereomer.

REFERENCES:
patent: 4369319 (1983-01-01), DeGraw, Jr. et al.
patent: 4393064 (1983-07-01), DeGraw, Jr. et al.

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