Diastereomeric pure trifluoromethyl ketone peptide derivatives a

Details Diastereomeric pure trifluoromethyl ketone peptide derivatives a Diastereomeric pure trifluoromethyl ketone peptide derivatives a

1998-01-27

1999-05-25

Richter, Johhann

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548566, 548568, 548569, 548570, 562444, 562449, 562450, 562451, C07D20712, C07C22948

Patent

active

059070439

ABSTRACT:
The present invention relates to pyrrolidine derivatives, and more particularly to the compound luoroacetyl)propyl!pyrrolidine-2-carboxamide, shown by formula I, and solvates thereof. The present invention also provides pharmaceutical compositions, intermediates and methods of preparation of the compound. The compound of formula I is an inhibitor of human neutrophil elastase and is useful in the treatment of diseases in which the enzyme is implicated, such as, for example, emphysema and acute respiratory distress syndrome (ARDS).

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patent: 5055450 (1991-10-01), Edwards et al.
patent: 5194588 (1993-03-01), Edwards et al.
patent: 5414132 (1995-05-01), Stein
Tetrahedron Lett. (1992), 33(30), 4279-82.
Tetrahedron: Asymmetry (1994), 5(2), 195-8.
J. Mol. Biol. (1988), 201(2), 423-8.
J. Medicinal Chemistry (1992) 35(4), 641-662.

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