Diastereomeric pure trifluoromethyl ketone peptide derivatives a

Details Diastereomeric pure trifluoromethyl ketone peptide derivatives a Diastereomeric pure trifluoromethyl ketone peptide derivatives a

1999-02-22

2000-03-14

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514428, 548537, 548539, 548540, A61K 3140, C07D20712

Patent

active

060373636

ABSTRACT:
The present invention relates to pyrrolidine derivative compounds, and more particularly to the compound (S)-1-[(S)-2-(4-methoxybenzamido)-3-methylbutyryl]-N-[(S)-2-methyl-1-(trif luoroacetyl)propyl]pyrrolidine-2-carboxamide, shown by the formula I, a pharmaceutical composition comprising this compound in a crystalline form and a process for preparing the pharmaceutical composition. The compound of formula I is an inhibitor of human neutrophil elastase and is useful in the treatment of diseases in which the enzyme is implicated, such as, for example, emphysema and acute respiratory distress syndrome (ARDS).

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