Diastereoisomers of 5-(1-hydroxy-2-(1-methyl-3-phenylpropylamino

Details Diastereoisomers of 5-(1-hydroxy-2-(1-methyl-3-phenylpropylamino Diastereoisomers of 5-(1-hydroxy-2-(1-methyl-3-phenylpropylamino

1978-09-21

1979-11-06

Waltz, Thomas

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260559A, C07C10326

Patent

active

041735838

ABSTRACT:
Disclosed is an improved process for separating 5-[1-hydroxy-2-(1-methyl-3-phenylpropylamino)ethyl]salicylamide into its two diastereoisomeric racemates; a process for converting either diastereoisomer into the other; and the use of one specified diastereoisomer as a superior antiarrhythmic agent.

REFERENCES:
patent: 3644353 (1972-02-01), Lunts et al.
patent: 3933911 (1976-01-01), Main
patent: 3949088 (1976-04-01), Samuelsson et al.
patent: 4000192 (1976-12-01), Lunts et al.
patent: 4000193 (1976-12-01), Lunts et al.
patent: 4012444 (1977-03-01), Lunts et al.
patent: 4041075 (1977-08-01), Smith
patent: 4101579 (1978-07-01), Hartley et al.
Farmer et al., CA 77:147680v (1972).

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