Diastereoisomeric tetrahydropyrido-(2,3,d) pyrimidine derivative

Details Diastereoisomeric tetrahydropyrido-(2,3,d) pyrimidine derivative Diastereoisomeric tetrahydropyrido-(2,3,d) pyrimidine derivative

1988-06-28

1990-05-22

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544279, 544225, 544226, 546288, 546289, 514184, C07D48704, A61K 31505

Patent

active

049278282

ABSTRACT:
The diastereoisomeric forms of N-(4-[2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]-pyrimidin-6-yl) ethyl]benzoyl)-L-glutamic acid are antineoplastic agents.
The compounds are prepared by separation of the diastereoisomeric form of the correspondingly protected glutamic derivatives and hydrolytic or hydrogenolytic removal of carboxylic acid and/or amino protecting groups.
Typical embodiments are the (R,S) and (S,S) forms of N-(4-[2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)e thyl]benzoyl)-L-glutamic acid.

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