Diarylmethyl and related compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Silicon containing doai

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S428000, C514S312000, C548S365100, C544S182000

Reexamination Certificate

active

08008278

ABSTRACT:
This invention provides compounds of formula I:wherein R1, R2, R3, R4, R5, R6, R7, Ar1, Ar2, E, a, b, c and z are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The compounds of this invention possess both β2adrenergic receptor agonist and muscarinic receptor antagonist activity and therefore, such compounds are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.

REFERENCES:
patent: 3192210 (1965-06-01), Lunsford et al.
patent: 3192221 (1965-06-01), Lunsford et al.
patent: 3247222 (1966-04-01), Lunsford
patent: 3732247 (1973-05-01), Helsley et al.
patent: 3984557 (1976-10-01), Welstead, Jr.
patent: 4002766 (1977-01-01), Welstead, Jr.
patent: 4026897 (1977-05-01), Nakagawa et al.
patent: 4250188 (1981-02-01), Gandolfi et al.
patent: 4299813 (1981-11-01), Snyder
patent: 4460581 (1984-07-01), Schromm et al.
patent: 4594343 (1986-06-01), Shanklin, Jr.
patent: 4810713 (1989-03-01), Yanni et al.
patent: 4894219 (1990-01-01), Baker et al.
patent: 4950674 (1990-08-01), Yanni et al.
patent: 4992474 (1991-02-01), Skidmore et al.
patent: 5070087 (1991-12-01), Teng et al.
patent: 5096890 (1992-03-01), Cross et al.
patent: 5233053 (1993-08-01), Cross et al.
patent: 5340831 (1994-08-01), Cross et al.
patent: 5607950 (1997-03-01), Alker et al.
patent: 5837724 (1998-11-01), Allen et al.
patent: 5932594 (1999-08-01), Cross et al.
patent: 6268533 (2001-07-01), Gao et al.
patent: 6362371 (2002-03-01), Moran et al.
patent: 6433027 (2002-08-01), Bozung et al.
patent: 6541669 (2003-04-01), Moran et al.
patent: 6576793 (2003-06-01), Moran et al.
patent: 6593497 (2003-07-01), Choi et al.
patent: 6653323 (2003-11-01), Moran et al.
patent: 6670376 (2003-12-01), Moran et al.
patent: 6693202 (2004-02-01), Aggen et al.
patent: 6713651 (2004-03-01), Moran et al.
patent: 6747043 (2004-06-01), Moran et al.
patent: 7317102 (2008-01-01), Mammen et al.
patent: 7829728 (2010-11-01), Mammen et al.
patent: 2003/0018019 (2003-01-01), Meade et al.
patent: 25 58 501 (1976-07-01), None
patent: 0 178 946 (1986-04-01), None
patent: 0 178 947 (1986-04-01), None
patent: 0 235 463 (1987-09-01), None
patent: 0 388 054 (1990-09-01), None
patent: WO 91/09013 (1991-06-01), None
patent: WO 98/54167 (1998-12-01), None
patent: WO 99/64031 (1999-12-01), None
patent: WO 99/64035 (1999-12-01), None
patent: WO 99/64043 (1999-12-01), None
patent: WO 02/066422 (2002-08-01), None
patent: WO 2004/074276 (2004-09-01), None
Cale et al., “A Series of Central Nervous System Stimulants Based on the 4-Substituted 3,3-Diphenyl-2-pyrrolidinone Skeleton. II”, J. Med. Chem., 10(2), pp. 214-222 (1967).
Glaxo Wellcome PLC, New long acting β2agonists, Expert Opin. Ther. Patents, 13(2), pp. 273-277 (2003).
Graul et al., “Darifenacin”, Drugs of the Future, 21(11), pp. 1105-1108 (1996).
Milecki et al., “Carbostyril Derivatives Having Potent β-Adrenergic Agonist Properties”, J.Med. Chem., 30, pp. 1563-1566 (1987).
Zlotos et al., “Muscarinic receptor agonists and antagonists”, Exp. Opin. Ther. Patents, 9(8), pp. 1029-1053 (1999).
Office Action from U.S. Appl. No. 10/813,745 (Feb. 13, 2007).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Diarylmethyl and related compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Diarylmethyl and related compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diarylmethyl and related compounds will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2756885

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.